{"id":2195,"date":"2025-05-07T00:00:00","date_gmt":"2025-05-07T00:00:00","guid":{"rendered":"urn:uuid:58c8e623-9336-4926-99b1-1a450370713e"},"modified":"2025-05-07T00:00:00","modified_gmt":"2025-05-07T00:00:00","slug":"dna-origamite3ci-yuan-gou-zao-wozuo-rufang-fa","status":"publish","type":"post","link":"https:\/\/www.sekaiken.com\/?p=2195","title":{"rendered":"DNA origami\u3067\uff13\u6b21\u5143\u69cb\u9020\u3092\u4f5c\u308b\u65b9\u6cd5"},"content":{"rendered":"<p>\u3057\u3070\u3089\u304f\u304a\u4f11\u307f\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u304c\u3001DNA origami\u306e\u89e3\u8aac\u3092\u7d9a\u3051\u307e\u3057\u3087\u3046\u3002<br \/>\n\u30cb\u30b3\u30cb\u30b3\u30de\u30fc\u30af\u306a\u3069\u306e2\u6b21\u5143\u306e\u69cb\u9020\u3092\u3088\u304f\u898b\u307e\u3059\u3002\u4e8c\u6b21\u5143\u69cb\u9020\u306f\u3001\u4e8c\u91cd\u3089\u305b\u3093\u3092\u3064\u304f\u308b2\u672c\u306e\u9577\u3055\u3092\u5909\u3048\u308b\u3068\u597d\u304d\u306a\u3068\u3053\u308d\u3067\u597d\u304d\u306a\u89d2\u5ea6\u3067\u66f2\u3052\u3089\u308c\u308b\u306e\u3067\u591a\u89d2\u5f62\u3092\u4f5c\u308b\u8981\u9818\u3067\u3067\u304d\u308b\u306e\u3067\u7c21\u5358\u306a\u306e\u3067\u3057\u3087\u3046\u3002\u3044\u307e\u3067\u3082\u3044\u308d\u3044\u308d\u8ad6\u6587\u304c\u51fa\u3066\u3044\u307e\u3059\u3002\u4e0b\u8a18\u8ad6\u6587\u306f\uff13\u3064\u306b\u308f\u3051\u3066\u30b9\u30dd\u30fc\u30af\u306e\u3088\u3046\u306a\u4e09\u89d2\u5f62\u69cb\u9020\u3092\u4f5c\u308b\u3068\u5b89\u5b9a\u306a\u69cb\u9020\u304c\u3067\u304d\u308b\u3068\u3044\u3046\u8ad6\u6587\u3067\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u9855\u3067\u5f62\u3092\u898b\u3066\u3044\u307e\u3059\u3002<br \/>\nhttps:\/\/www.science.org\/doi\/10.1126\/sciadv.abn0039<br \/>\n\u4e09\u6b21\u5143\u69cb\u9020\u306f\u3068\u3044\u3046\u3068\u3001DNA\u306e\u9577\u3044\u8f2a\u3092\u3064\u304f\u308a\u3001\u305d\u308c\u306b&rdquo;staple&rdquo;\uff08\u30db\u30c3\u30c1\u30ad\u30b9\uff09\u306e\u3088\u3046\u306a\u7559\u3081\u5177\u3068\u3057\u3066\u77ed\u3044DNA\u3092\u3042\u3061\u3053\u3061\u306b\u3044\u308c\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u597d\u304d\u306a3\u6b21\u5143\u69cb\u9020\u304c\u4f5c\u308c\u308b\u305d\u3046\u3067\u3059\u3002\u8a2d\u8a08\u306f\u5927\u5909\u3060\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u3044\u308d\u3044\u308d\u306a\u5f62\u3092\u4f5c\u3063\u305f\u8ad6\u6587\u304c\u4e0b\u8a18\u3067\u3059\u3002<br \/>\nhttps:\/\/www.nature.com\/articles\/s41427-023-00470-3<br \/>\n\u30cb\u30b3\u30cb\u30b3\u30de\u30fc\u30af\u3082\u6700\u521d\u306e1\u03bcm\u306e\u3082\u306e\u3088\u308a\u305a\u3063\u3068\u5c0f\u3055\u304460nm\u76f4\u5f84\u306e\u3082\u306e\u304c\u3067\u304d\u3066\u3044\u307e\u3059\u306d\u300250nm\u306e\u58fa\u3084\u3046\u305a\u307e\u304d\u3001\u30ed\u306e\u5b57\u578b\u306e\u65ad\u9762\u3092\u6301\u3064\u30d1\u30a4\u30d7\u3001\u82b1\u306e\u7d75\u306a\u3069\u3001\u82b8\u8853\u7684\u306a\u3082\u306e\u304cFig.1\u306b\u3044\u308d\u3044\u308d\u8f09\u3063\u3066\u3044\u307e\u3059\u3002\u56f32\u306f\u30e2\u30ca\u30ea\u30b6\u304c\u5370\u8c61\u7684\u3067\u3059\u3002\u304b\u306a\u308a\u81ea\u7531\u306b\uff13\u6b21\u5143\u69cb\u9020\u3092\u4f5c\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u6570\u5341nm\u306e\u8907\u96d1\u306a\u69cb\u9020\u3092\u5927\u91cf\u751f\u7523\u3067\u304d\u308b\u65b9\u6cd5\u3068\u3057\u3066\u306fDNA origami\u304c\u4e00\u756a\u3067\u3057\u3087\u3046\u3002\u767a\u660e\u8005\u306eRothemund\u306f\u30ce\u30fc\u30d9\u30eb\u8cde\u306e\u4e0b\u99ac\u8a55\u306b\u306f\u6642\u3005\u540d\u524d\u304c\u6319\u304c\u308a\u307e\u3059\u3002\u307e\u3060\u82e5\u3044\u306e\u3067\u3001\u3044\u3064\u304b\u3068\u308b\u3068\u601d\u3044\u307e\u3059\u3002<br \/>\n\u30a6\u30a3\u30eb\u30b9\u7a0b\u5ea6\u306e\u5927\u304d\u3055\u306e\u597d\u304d\u306a\uff13\u6b21\u5143\u69cb\u9020\u304c\u4f5c\u308c\u308b\u3068\u3057\u3066\u3001\u4f55\u306b\u4f7f\u3046\u304b\u3068\u3044\u3046\u3068\u3001\u3053\u306e\u8ad6\u6587\u3067\u306f\u751f\u4f53\u5206\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3055\u305b\u3066\u4f8b\u3048\u3070\u514d\u75ab\u306e\u5236\u5fa1\u3001\u8102\u8cea\u4e8c\u91cd\u819c\u306e\u5236\u5fa1\u3084\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u306b\u4f7f\u304a\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u69cb\u9020\u306e\u67a0\u7d44\u307f\u306f\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u3067\u3001\u52d5\u304d\u3092\u53d6\u308a\u5165\u308c\u3066\u6a5f\u68b0\u306b\u3057\u305f\u3044\u3067\u3059\u306d\u3002\u660e\u65e5\u8a73\u3057\u304f\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u82f1\u8a9e\u306f https:\/\/www.nature.com\/articles\/s41427-023-00470-3<\/p>\n<p>\u201dIn 2014, inspired by the \u201ccytoskeleton\u2013membrane protein\u2013lipid bilayer\u201d principle of the cell membrane, an exciting strategy termed \u201cframe-guided assembly (FGA)\u201d was proposed by the Liu group to direct the assembly of amphiphiles\u201d<br \/>\ninspired by \uff5e\u306b\u523a\u6fc0\u3092\u3046\u3051\u3066\u3001\uff5e\u306b\u7740\u60f3\u3092\u5f97\u3066<br \/>\ncytoskeleton \u7d30\u80de\u9aa8\u683c<br \/>\ncell membrane \u7d30\u80de\u819c<br \/>\namphiphiles \u4e21\u89aa\u5a92\u6027\u5206\u5b50<\/p>\n<p>\u201dAn important goal of our exploration of life processes is to understand the causes of disease and develop effective therapies. In past decades, with the development of nanotechnology, various nanocarriers have come into the spotlight and attracted tremendous attention because they can improve the effectiveness and minimize the adverse effects of conventional drug.&rdquo;<br \/>\nexploration \u63a2\u691c<br \/>\ndevelop effective therapies \u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3059\u308b<br \/>\nIn past decades \u3053\u3053\u6570\u5341\u5e74\u306f\u3001<br \/>\nnanocarriers \u30ca\u30ce\u306e\u904b\u3073\u624b<br \/>\nattracted tremendous attention\u3000\u305f\u3044\u3078\u3093\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u305f<br \/>\nthe adverse effects of conventional drug \u5f93\u6765\u306e\u85ac\u5264\u306e\u60aa\u3044\u526f\u4f5c\u7528<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3057\u3070\u3089\u304f\u304a\u4f11\u307f\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u304c\u3001DNA origami\u306e\u89e3\u8aac\u3092\u7d9a\u3051\u307e\u3057\u3087\u3046\u3002 \u30cb\u30b3\u30cb\u30b3\u30de\u30fc\u30af\u306a\u3069\u306e2\u6b21\u5143\u306e\u69cb\u9020\u3092\u3088\u304f\u898b\u307e\u3059\u3002\u4e8c\u6b21\u5143\u69cb\u9020\u306f\u3001\u4e8c\u91cd\u3089\u305b\u3093\u3092\u3064\u304f\u308b2\u672c\u306e\u9577\u3055\u3092\u5909\u3048\u308b\u3068\u597d\u304d\u306a\u3068\u3053\u308d\u3067\u597d\u304d\u306a\u89d2\u5ea6\u3067\u66f2\u3052\u3089\u308c\u308b\u306e\u3067\u591a\u89d2\u5f62\u3092\u4f5c\u308b\u8981\u9818\u3067\u3067\u304d\u308b\u306e\u3067\u7c21\u5358\u306a\u306e\u3067\u3057\u3087\u3046\u3002\u3044\u307e\u3067\u3082\u3044\u308d\u3044\u308d\u8ad6\u6587\u304c\u51fa\u3066\u3044\u307e\u3059\u3002\u4e0b\u8a18\u8ad6\u6587\u306f\uff13\u3064\u306b\u308f\u3051\u3066\u30b9\u30dd\u30fc\u30af\u306e\u3088\u3046\u306a\u4e09\u89d2\u5f62\u69cb\u9020\u3092\u4f5c\u308b\u3068\u5b89\u5b9a\u306a\u69cb\u9020\u304c\u3067\u304d\u308b\u3068\u3044\u3046\u8ad6\u6587\u3067\u3001\u30af\u30e9\u30a4\u30aa\u96fb\u9855\u3067\u5f62\u3092\u898b\u3066\u3044\u307e\u3059\u3002 https:\/\/www.science.org\/doi\/10.1126\/sciadv.abn0039 \u4e09\u6b21\u5143\u69cb\u9020\u306f\u3068\u3044\u3046\u3068\u3001DNA\u306e\u9577\u3044\u8f2a\u3092\u3064\u304f\u308a\u3001\u305d\u308c\u306b&rdquo;staple&#038;&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[42,44],"tags":[5,7],"class_list":["post-2195","post","type-post","status-publish","format-standard","hentry","category-tech","category-materials","tag-tech","tag-materials"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2195"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2195\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}