\u30ad\u30e9\u30fcT\u7d30\u80de\u306e2\u3064\u76ee\u306e\u6b66\u5668\u306f\u7d30\u80de\u306e\u81ea\u7206\u30b9\u30a4\u30c3\u30c1\u3092\u62bc\u3059\u30bf\u30f3\u30d1\u30affasL(fas ligand)\u3067\u3059\u3002fas\u306f\u30d5\u30a1\u30b9\u3068\u8aad\u3080\u307f\u305f\u3044\u3067\u3059\u3002\u6628\u65e5\u8aac\u660e\u3057\u305f\u3088\u3046\u306b\u3001\u7d30\u80de\u304c\u3042\u308b\u30ec\u30d9\u30eb\u4ee5\u4e0a\u58ca\u308c\u308b\u3068\u3001DNA\u3084\u90e8\u54c1\u3092\u7d30\u5206\u5316\u3057\u3066\u304b\u3089\u7d30\u80de\u819c\u3092\u7834\u308b\u904e\u7a0b\u3067\u3042\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u8d77\u308a\u307e\u3059\u304c\u3001\u305d\u308c\u3092\u5916\u90e8\u523a\u6fc0\u306e\u307f\u3067\u8d77\u3053\u3059\u6a5f\u80fd\uff08\uff1d\u81ea\u7206\u30b9\u30a4\u30c3\u30c1\uff09\u304c\u6b63\u5e38\u306a\u7d30\u80de\u306b\u306f\u305d\u306a\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304c\u7d30\u80de\u819c\u306b\u3042\u308bfas\u30bf\u30f3\u30d1\u30af\uff08fas receptor, fasR\u3068\u3082\u3044\u3046\uff09\u3067\u3001\u305d\u3053\u306b\u30ad\u30e9\u30fcT\u7d30\u80de\u304c\u653e\u51fa\u3059\u308bfasL\u304c\u304f\u3063\u3064\u304f\u3068\u52d5\u4f5c\u3057\u307e\u3059\u3002
\nfas\u306e\u69cb\u9020\u306f\u4e0b\u8a18\u3002
\nhttps:\/\/www.rcsb.org\/3d-view\/3THM\/1
\nfasL\uff08\u4e0b\u8a18Decoy(\u505c\u6b62\u88c5\u7f6e)\u304c\u3064\u3044\u3066\u3044\u308b\uff09\u306e\u69cb\u9020\u306f\u4e0b\u8a18\u3067\u3059\u3002fasL\u306f\uff13\u91cf\u4f53\u3067\u3059\u304c\u3001\u52d5\u4f5c\u306b\u306f\u3053\u308c\u304c2\u7d44\u5fc5\u8981\u3060\u305d\u3046\u3067\u3059\u3002
\nhttps:\/\/www.rcsb.org\/3d-view\/4MSV\/1
\n\u304f\u3063\u3064\u3044\u305f\u3068\u304d\u306e\u69cb\u9020\u30e2\u30c7\u30eb\u306f\u3061\u3087\u3063\u3068\u53e4\u3044\u3067\u3059\u304c\u4e0b\u8a18\u304c\u51fa\u3066\u304d\u307e\u3057\u305f\u3002
\nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925818390562
\nfas\u3082fasL\u3082\u3001\u3053\u3093\u306a\u5927\u305d\u308c\u305f\u3053\u3068\u3092\u3059\u308b\u306b\u3057\u3066\u306f\u5c0f\u3055\u3044\u3067\u3059\u306d\u3002\u52d5\u4f5c\u6a5f\u69cb\u306f\u4e0b\u8a18\u306e\u6a21\u5f0f\u56f3\u304c\u3042\u308a\u307e\u3059\u3002
\nhttps:\/\/en.wikipedia.org\/wiki\/Fas_ligand#\/media\/File:Fas_signaling.jpg
\n\u305f\u3060\u3057\u3001\u5168\u8c8c\u306f\u307e\u3060\u7814\u7a76\u4e2d\u306e\u3088\u3046\u3067\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u4ee5\u5916\u306e\u6a5f\u80fd\u304c\u898b\u3064\u304b\u3063\u305f\u3001\u306a\u3069\u3068\u3044\u3046\u8ad6\u6587\u304c\u6700\u8fd1\u51fa\u305f\u308a\u3057\u3066\u3044\u307e\u3059\u3002
\n\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u304b\u3089\u304f\u308a\u7d30\u5de5\u3001\u5408\u4f53\u30ed\u30dc\uff08\u82e5\u3044\u4eba\u306f\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30de\u30fc\u306e\u6620\u753b\u306e\u65b9\u304c\u306a\u3058\u307f\u304c\u3042\u308b\uff1f\uff09\u306e\u3088\u3046\u306b\u5909\u5f62\u3059\u308b\u6a5f\u68b0\u3060\u3068\u601d\u3046\u3068\u30a4\u30e1\u30fc\u30b8\u304c\u3064\u304b\u3081\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u5909\u5f62\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3082\u3068\u3082\u3068\u304f\u3063\u3064\u3044\u3066\u3044\u305f\u5225\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u96e2\u308c\u3066\u62e1\u6563\u3057\u3066\uff08\u6cf3\u3044\u3067\uff09\u884c\u3063\u3066\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u304f\u3063\u3064\u304f\u3088\u3046\u306a\u9023\u7d9a\u904e\u7a0b\u304c\u8d77\u308a\u307e\u3059\u3002\u305d\u308c\u3089\u306f\u4e00\u672c\u306e\u77e2\u5370\u3067\u3064\u306a\u304c\u3063\u305f\u52d5\u4f5c\u3067\u306f\u306a\u304f\u3001\uff11\u3064\u306e\u52d5\u4f5c\u306b2\u3064\u306e\u4fe1\u53f7\u304c\u5fc5\u8981\u3060\u3063\u305f\u308a1\u3064\u306e\u52d5\u4f5c\u304c\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u305f\u308a\u3001\u7af6\u5408\u3059\u308b\u30b9\u30c8\u30c3\u30d1\u30fc\u304c\u3042\u3063\u305f\u308a\u3057\u307e\u3059\u3002\u52d5\u4f5c\u901f\u5ea6\u3084\u52d5\u4f5c\u78ba\u7387\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6fc3\u5ea6\u306b\u4f9d\u5b58\u3059\u308b\u306e\u3067\u3001\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u4f3c\u305f\u8907\u96d1\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3068\u307f\u306a\u305b\u308b\u3067\u3057\u3087\u3046\u3002\u305f\u3060\u3057\u3001\u8133\u306e\u4fe1\u53f7\u51e6\u7406\u306b\u6bd4\u3079\u308b\u3068\u52d5\u4f5c\u306b\u6642\u9593\u304c\u304b\u304b\u308a\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u308b\u307e\u3067\u306b20\u5206\u7a0b\u5ea6\u3001\u30ad\u30e9\u30fcT\u7d30\u80de\u306a\u3069\u514d\u75ab\u7d30\u80de\u306e\u5897\u6b96\u307e\u3067\u5165\u308c\u308b\u3068\u6570\u65e5\u3067\u3059\u3002\u98a8\u90aa\u3092\u3072\u3044\u305f\u3068\u304d\u306b\u6cbb\u308a\u59cb\u3081\u308b\u307e\u3067\u306e\u6642\u9593\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u60c5\u5831\u3060\u3051\u3067\u306a\u304f\u30cf\u30fc\u30c9\u30a6\u30a7\u30a2\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u306e\u3067\u6642\u9593\u304c\u304b\u304b\u308b\u306e\u306f\u5f53\u7136\u3068\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u3053\u3046\u3044\u3046\u306e\u3092\u898b\u308b\u3068\u3001\u751f\u547d\u306f\u5c0a\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n
\u82f1\u8a9e\u306f\u9069\u5f53\u306b\u62fe\u3063\u3066\u307f\u307e\u3059\u3002
\nligand \u4eca\u78ba\u8a8d\u3057\u305f\u3089\u3001\u30ea\u30ac\u30f3\u30c9\u3067\u306f\u306a\u304f\u3000\u3089\u30a4\u30ac\u30f3\u30c9\u3000\u3068\u8aad\u3080\u307f\u305f\u3044\u3067\u3059\u3002
\ncaspase \u30ad\u30e3\u30b9\u30d1\u30fc\u30bc\u3000\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u52d5\u4f5c\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u3002caspase 3, 8, 9\u304c\u4e0a\u8a18\u306b\u306f\u51fa\u3066\u304d\u307e\u3059\u3002\u540d\u524d\u306e\u7531\u6765\u306f\u4f55\u3060\u308d\u3046\u3068\u601d\u3063\u3066\u691c\u7d22\u3057\u305f\u3089AI\u304c\u8a00\u3046\u306b\u306f\uff1a
\n\u201dA caspase is called a caspase because the name is derived from “cysteine-dependent aspartate-specific protease,” reflecting the fact that these enzymes are cysteine proteases which specifically cleave protein substrates at an aspartic acid residue; essentially, “caspase” is a shortened version of this descriptive phrase describing its enzymatic activity. \u201d
\ncysteine \u30b7\u30b9\u30c6\u30a4\u30f3\u3000
\nprotease \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc \u3000\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20
\ncleave \u30af\u308a\u30fc\u30f4\u3000\u958b\u88c2\u3055\u305b\u308b\u3001\u5288\u958b\u3059\u308b
\naspartic acid \u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178
\nresidue \u300c\u30ec\u300d\u30b9\u30a3\u30c7\u30e5\u30fc\u3000\u6b8b\u57fa\u3000\u3068\u8a33\u3057\u307e\u3059\u3002\u3000\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u3092\u6307\u3059\u3053\u3068\u3070\u3002
\ndescriptive \u8aac\u660e\u7684\u306a\u3000\u3000describe \u63cf\u5199\u3059\u308b
\n\u201dDcR3: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor of the tumor necrosis factor superfamily that binds to FasL, LIGHT, and TL1A. DcR3 is a soluble receptor that has no signal transduction capabilities (hence a “decoy”) and functions to prevent FasR-FasL interactions by competitively binding to membrane-bound Fas ligand and rendering them inactive.\u201d
\ndecoy \u30c7\u30b3\u30a4\u3000\u304a\u3068\u308a
\nno signal transduction capabilities \u3000\u4fe1\u53f7\u4f1d\u9054\u80fd\u529b\u3092\u3082\u305f\u306a\u3044\u3000\u3000transuduction\u306f\u751f\u5316\u5b66\u7528\u8a9e\u3060\u3068\u304a\u3082\u3044\u307e\u3059\u3002
\nhence \u305d\u308c\u3086\u3048
\nrender \u30ec\u30f3\u30c0\u30fc = make\u3000 ~\u3055\u305b\u308b \u3000\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3067\u753b\u50cf\u3092\u8868\u793a\u3059\u308b\u904e\u7a0b\u3067\u30ec\u30f3\u30c0\u30ea\u30f3\u30b0\u3068\u3044\u3046\u8a00\u8449\u304c\u3042\u308a\u307e\u3059\u3000\u3000render them inactive \u3067\u3001\u300c\u52d5\u4f5c\u3057\u306a\u3044\u72b6\u614b\u306b\u3059\u308b\u300d<\/p>\n","protected":false},"excerpt":{"rendered":"
\u30ad\u30e9\u30fcT\u7d30\u80de\u306e2\u3064\u76ee\u306e\u6b66\u5668\u306f\u7d30\u80de\u306e\u81ea\u7206\u30b9\u30a4\u30c3\u30c1\u3092\u62bc\u3059\u30bf\u30f3\u30d1\u30affasL(fas ligand)\u3067\u3059\u3002fas\u306f\u30d5\u30a1\u30b9\u3068\u8aad\u3080\u307f\u305f\u3044\u3067\u3059\u3002\u6628\u65e5\u8aac\u660e\u3057\u305f\u3088\u3046\u306b\u3001\u7d30\u80de\u304c\u3042\u308b\u30ec\u30d9\u30eb\u4ee5\u4e0a\u58ca\u308c\u308b\u3068\u3001DNA\u3084\u90e8\u54c1\u3092\u7d30\u5206\u5316\u3057\u3066\u304b\u3089\u7d30\u80de\u819c\u3092\u7834\u308b\u904e\u7a0b\u3067\u3042\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u8d77\u308a\u307e\u3059\u304c\u3001\u305d\u308c\u3092\u5916\u90e8\u523a\u6fc0\u306e\u307f\u3067\u8d77\u3053\u3059\u6a5f\u80fd\uff08\uff1d\u81ea\u7206\u30b9\u30a4\u30c3\u30c1\uff09\u304c\u6b63\u5e38\u306a\u7d30\u80de\u306b\u306f\u305d\u306a\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304c\u7d30\u80de\u819c\u306b\u3042\u308bfas\u30bf\u30f3\u30d1\u30af\uff08fas receptor, fasR\u3068\u3082\u3044\u3046\uff09\u3067\u3001\u305d\u3053\u306b\u30ad\u30e9\u30fcT\u7d30\u80de\u304c\u653e\u51fa\u3059\u308bfasL\u304c\u304f\u3063\u3064\u304f\u3068\u52d5\u4f5c\u3057\u307e\u3059\u3002 fas\u306e\u69cb\u9020\u306f\u4e0b\u8a18\u3002 https:\/\/www.rcsb.org\/3d-view\/3THM\/1 fasL\uff08\u4e0b\u8a18Deco…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[9],"class_list":["post-2153","post","type-post","status-publish","format-standard","hentry","category-bio","tag-bio"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2153"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2153\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}