\u30ad\u30e9\u30fcT\u7d30\u80de\uff08\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u3001cytotoxic T cell\uff09\u306e\u6b66\u5668\u306f2\u7a2e\u985e\u3042\u308a\u307e\u3059\u3002\uff11\u3064\u306f2\u7d44\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001perforin \u3068granzyme\u3067\u3059\u3002\u3082\u3046\u4e00\u3064\u306ffas\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u4eca\u65e5\u306f1\u3064\u76ee\u3092\u8aac\u660e\u3057\u307e\u3059\u3002
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E3%83%91%E3%83%BC%E3%83%95%E3%82%A9%E3%83%AA%E3%83%B3
\nperforin\u306fT\u7d30\u80de\u306e\u4e2d\u3067\u306f\u300c\u9846\u7c92\u300d\u3068\u3044\u3046\u5c0f\u80de\u306b\u3057\u307e\u308f\u308c\u3066\u3044\u3066\u3001\u9846\u7c92\u304c\u7d30\u80de\u819c\u307e\u3067\u79fb\u52d5\u3057\u3066\uff08\u2190\u3053\u3053\u306f\u63a8\u6e2c\uff09\u5916\u90e8\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u304a\u305d\u3089\u304f\u3053\u306e\u6bb5\u968e\u3067\u306f\u6a19\u7684\u7d30\u80de\u306f\u3054\u304f\u8fd1\u304f\u306b\u3044\u3066\u3001perforin\u306f\u7d30\u80de\u819c\u306b\u304f\u3063\u3064\u304d\u307e\u3059\u3002perforin\u304c24\u500b\u96c6\u5408\u3059\u308b\u3068\u7d30\u80de\u819c\u306b\u7a74\u304c\u958b\u304d\u307e\u3059\u3002\u7a74\u306e\u56f3\u304c\u4e0b\u8a18\u306e\u8ad6\u6587\u306b\u51fa\u3066\u3044\u307e\u3059\u3002\u5185\u5f84110\u212b\u3001\u5916\u5f84245\u212b\u3067\u3059\u3002
\nhttps:\/\/www.science.org\/doi\/10.1126\/sciadv.abk3147
\n\u305d\u308c\u3060\u3051\u3067\u306f\u6a19\u7684\u7d30\u80de\u306f\u6b7b\u306a\u306a\u3044\u306e\u3067\u3001\u540c\u6642\u306b\u30ad\u30e9\u30fcT\u7d30\u80de\u304b\u3089granzyme\u3068\u3044\u3046\u9175\u7d20\u304c\u653e\u51fa\u3055\u308c\u3001\u6a19\u7684\u7d30\u80de\u306e\u7a74\u304b\u3089\u62e1\u6563\u3067\u4e2d\u306b\u5165\u308a\u307e\u3059\u3002\u3053\u306egranzyme\u306e\u3046\u3061\u306egranzyme B\u306f\u3088\u304f\u8abf\u3079\u3089\u308c\u3066\u3044\u3066\u3001\u306f\u6a19\u7684\u7d30\u80de\u306ecaspase-3\u3068\u3044\u3046\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u3053\u308c\u304cDNA\u5207\u65ad\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3068\u3068\u3082\u306b\u3001granzyme B\u304c\u6d3b\u6027\u5316\u3059\u308b\u3082\u3046\u4e00\u3064\u306eBid\u3068\u3044\u3046\u305f\u3093\u3071\u304f\u8cea\u304c\u6700\u7d42\u7684\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u819c\u306e\u900f\u904e\u6027\u3092\u5909\u5316\u3055\u305b\u3001cytochrome C\u306e\u3088\u3046\u306a\u91cd\u8981\u306a\u5206\u5b50\u304c\u6d41\u51fa\u3057\u305f\u3053\u3068\u304c\u691c\u77e5\u3055\u308c\u308b\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u306e\u81ea\u7206\uff09\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059\u3002\u7d30\u80de\u306f\u3042\u308b\u7a0b\u5ea6\u640d\u50b7\u3059\u308b\u3068\u5206\u5b50\u304c\u5909\u8cea\u3059\u308b\u524d\u306b\u81ea\u7206\u3059\u308b\u3088\u3046\u306b\u3067\u304d\u3066\u3044\u3066\u3001\u305d\u306e\u7834\u7247\u3092\u514d\u75ab\u7d30\u80de\u304c\u53d6\u308a\u8fbc\u3093\u3067\u300c\u3053\u306e\u3088\u3046\u306a\u30e4\u30d0\u3044\u7d30\u80de\u304c\u3044\u308b\u305e\u300d\u3068T\u7d30\u80de\u306b\u63d0\u793a\u3057\u3066\u30a6\u30a3\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u3084\u304c\u3093\u7d30\u80de\u3092\u7834\u58ca\u3059\u308b\u4ed5\u7d44\u307f\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/en.wikipedia.org\/wiki\/Granzyme
\nhttps:\/\/www.rcsb.org\/3d-view\/1IAU\/1
\n\u5b66\u751f\u306e\u6642\u306b\u7fd2\u3063\u305f\u7d30\u80de\u751f\u7269\u5b66\u306b\u304f\u3089\u3079\u3066\u60c5\u5831\u304c\u98db\u8e8d\u7684\u306b\u5897\u3048\u3066\u3044\u308b\u306e\u3067\u9a5a\u304d\u307e\u3059\uff08\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u3044\u3046\u306e\u304c\u3042\u308b\u304c\u4ed5\u7d44\u307f\u306f\u5168\u90e8\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3001\u3068\u7fd2\u3063\u305f\uff09\u3002\u73fe\u4ee3\u306f\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u3067\u8fbf\u3063\u3066\u3044\u304f\u3060\u3051\u3067\u304b\u306a\u308a\u52c9\u5f37\u3067\u304d\u307e\u3059\u306d\u3002<\/p>\n
\u82f1\u8a9e\u306f\u3000https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/perforin\u3000\u304b\u3089\u3002
\n“Perforins or pore-forming proteins are cytolytic effector proteins degranulated from NK cells and cytotoxic T lymphocytes.”
\n\u203b perforin < pore forming protein \u304b\u3089\u540d\u524d\u304c\u3064\u3044\u305f\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002
\n“Perforins also acts as calcium-dependent glycoproteins that are stored and released from the secretory granules (SGs) that contain broad substrate specificities.”
\nsecretory \u5206\u6ccc\u3059\u308b
\ngranule \u9846\u7c92
\nsubstrate \u3053\u306e\u5206\u91ce\u3067\u306f\u300c\u57fa\u8cea\u300d\u3068\u8a33\u3057\u307e\u3059\u3002
\n“This is important for forming arc- and ring-shaped transmembrane pores resulting in osmotic disruption at the target cell membrane. “
\n“Fatal immune dysregulation results in loss of perforin expression, while partial loss leads to malignancies that may result in lymphoma and leukemia.”
\ndysregulation \u5236\u5fa1\u4e0d\u826f\u3000\u3000dys\u306f\u300c\u4e0d\u826f\u300d dysfunctioning
\nmalignancies \u300c\u30de\u300d\u308a\u30cb\u30e3\u30f3\u30b7\u30fc\u30ba\u3000\u60aa\u6027\u306e\u3082\u306e
\nlymphoma and leukemia \u30ea\u30f3\u30d1\u816b\u3068\u767d\u8840\u75c5
\n“Perforin is also reported to exhibit its crucial role in lymphocyte-mediated cell death pathways, whereas the perforin\u2013granzyme pathway attracts the researchers towards the understanding of pathophysiological conditions like viral immunity and the crosslink between various inflammatory and neoplastic diseases linked with cancer.”
\npathophysiological \u75c5\u614b\u751f\u7406\u5b66\u306e\u3000\u3000patho=\u75c5\u3000pathogen\uff1d\u75c5\u539f\u4f53\u3000physiology=\u751f\u7406\u5b66
\nviral immunity \u300c\u30f4\u30a1\u300d\u30a4\u30e9\u308b < virus\u306e\u5f62\u5bb9\u8a5e\u3000\u30a6\u30a3\u30eb\u30b9\u514d\u75ab
\ninflammatory \u708e\u75c7\u6027\u306e
\nneoplastic \u65b0\u751f\u7269\u306e\u3001\u816b\u760d\u6027\u306e<\/p>\n","protected":false},"excerpt":{"rendered":"
\u30ad\u30e9\u30fcT\u7d30\u80de\uff08\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u3001cytotoxic T cell\uff09\u306e\u6b66\u5668\u306f2\u7a2e\u985e\u3042\u308a\u307e\u3059\u3002\uff11\u3064\u306f2\u7d44\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001perforin \u3068granzyme\u3067\u3059\u3002\u3082\u3046\u4e00\u3064\u306ffas\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u4eca\u65e5\u306f1\u3064\u76ee\u3092\u8aac\u660e\u3057\u307e\u3059\u3002 https:\/\/ja.wikipedia.org\/wiki\/%E3%83%91%E3%83%BC%E3%83%95%E3%82%A9%E3%83%AA%E3%83%B3 perforin\u306fT\u7d30\u80de\u306e\u4e2d\u3067\u306f\u300c\u9846\u7c92\u300d\u3068\u3044\u3046\u5c0f\u80de\u306b\u3057\u307e\u308f\u308c\u3066\u3044\u3066\u3001\u9846\u7c92\u304c\u7d30\u80de\u819c\u307e\u3067\u79fb\u52d5\u3057\u3066\uff08\u2190\u3053\u3053\u306f\u63a8\u6e2c\uff09\u5916\u90e8\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u304a\u305d\u3089\u304f\u3053\u306e\u6bb5\u968e\u3067\u306f\u6a19\u7684\u7d30\u80de\u306f\u3054\u304f\u8fd1\u304f\u306b\u3044\u3066\u3001perforin\u306f\u7d30\u80de\u819c\u306b\u304f\u3063\u3064…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[9],"class_list":["post-2152","post","type-post","status-publish","format-standard","hentry","category-bio","tag-bio"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2152"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2152\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}