\u30d2\u30c8\u306e\u7d30\u80de\u306e\u8868\u9762\u306b\u306f\u3001\u81ea\u4ed6\u3092\u533a\u5225\u3057\u305f\u308a\u514d\u75ab\u7d30\u80de\u3068\u60c5\u5831\u3092\u3084\u308a\u53d6\u308a\u3059\u308b\u305f\u3081\u306b\u7cd6\u30bf\u30f3\u30d1\u30af\u304c\u3073\u3063\u3057\u308a\u751f\u3048\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u305d\u308c\u3092MHC\u3001\u5225\u540dHLA\u3068\u547c\u3073\u307e\u3059\u3002
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E4%B8%BB%E8%A6%81%E7%B5%84%E7%B9%94%E9%81%A9%E5%90%88%E9%81%BA%E4%BC%9D%E5%AD%90%E8%A4%87%E5%90%88%E4%BD%93
\nMHC\u5206\u5b50\u306b\u306f\u591a\u304f\u306e\u578b\uff08\u5c11\u306a\u304f\u3068\u30822\u4e07\u4f59\uff09\u304c\u3042\u308a\u3001\uff11\u3064\u306e\u500b\u4f53\u306f\u7236\u6bcd\u304b\u3089\u53d7\u3051\u7d99\u3044\u3060\u591a\u6570\u306e\u578b\u3092\u540c\u6642\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u514d\u75ab\u7d30\u80de\u306f\u3053\u306e\u578b\u306e\u5206\u5e03\u3067\u81ea\u4ed6\u3092\u8b58\u5225\u3057\u3066\u304a\u308a\u3001\u81d3\u5668\u79fb\u690d\u306e\u969b\u306e\u62d2\u7d76\u53cd\u5fdc\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002\u8840\u6db2\u306e\u5834\u5408\u306f\u767d\u8840\u7403\u3060\u3051\u306a\u306e\u3067ABO\u3068RH\u306e\u8840\u6db2\u578b\u3067\u3059\u304c\u3001\u4ed6\u306e\u81d3\u5668\u306e\u5834\u5408\u306f\u578b\u306e\u7a2e\u985e\u304c\u305a\u3063\u3068\u591a\u3044\u305f\u3081\u3001\u81ea\u5206\u306b\u9069\u5408\u3057\u305f\u79fb\u690d\u30c9\u30ca\u30fc\u3092\u63a2\u3059\u306e\u304c\u305f\u3044\u3078\u3093\u3067\u3059\u3002
\n\u3084\u3084\u3053\u3057\u3044\u306e\u306f\u3001MHC\u5206\u5b50\u306b\u306f\u6e9d\u304c\u3042\u308a\u3001\u305d\u3053\u306b\u4ed6\u306e\u5206\u5b50\u3092\u304f\u3063\u3064\u3051\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002MHC\u30af\u30e9\u30b9I\u3068\u3044\u3046\u5206\u5b50\u306f\u7d30\u80de\u81ea\u8eab\u306e\u7523\u7269\u3092\u304f\u3063\u3064\u3051\u3066\u3044\u308b\u305f\u3081\u3001\u30a6\u30a3\u30eb\u30b9\u611f\u67d3\u3084\u66b4\u8d70\u3057\u305f\u7d30\u80de\uff08\u304c\u3093\u7d30\u80de\uff09\u3078\u306e\u514d\u75ab\u53cd\u5fdc\u306b\u95a2\u9023\u3057\u307e\u3059\u3002MHC\u30af\u30e9\u30b9II\u3068\u3044\u3046\u5206\u5b50\u306f\u767d\u8840\u7403\u304c\u3082\u3063\u3066\u304a\u308a\u3001\u8caa\u98df\u30fb\u5206\u89e3\u3057\u305f\u7d30\u83cc\u7b49\u306e\u5916\u6765\u6027\u306e\u6297\u539f\u3092\u304f\u3063\u3064\u3051\u307e\u3059\u3002\u672c\u6765\u306eT\u7d30\u80de\u306f\u81ea\u5df1\u306e\u514d\u75ab\u7d30\u80de\uff08B\u7d30\u80de\u3001\u6a39\u72b6\u7d30\u80de\uff09\u306eMHC\u5206\u5b50\u304c\u304f\u3063\u3064\u3051\u3066\u3044\u308b\u5206\u5b50\u306b\u3057\u304b\u514d\u75ab\u5fdc\u7b54\u3057\u307e\u305b\u3093\u304c\u3001CAR-T\u7d30\u80de\u306f\u304c\u3093\u7d30\u80de\u306e\u3082\u3064\u6297\u539f\uff08\u60a3\u8005\u304b\u3089\u53d6\u308a\u51fa\u3059\uff09\u3092\u76f4\u63a5\u8a8d\u8b58\u3059\u308b\u3088\u3046\u306b\u4f5c\u308b\u3088\u3046\u3067\u3059\u3002
\n\u5b9f\u969b\u306eMHC\u5206\u5b50\u306f\u4e0b\u8a18\u306e\u3088\u3046\u306a\u69cb\u9020\u3092\u3057\u3066\u304a\u308a\u3001\u304f\u3063\u3064\u3051\u3066\u3044\u308b\u6297\u539f\u5206\u5b50\uff08\u6297\u539f\u6c7a\u5b9a\u57fa\uff09\u306f8~10\u30a2\u30df\u30ce\u9178\u306e\u30da\u30d7\u30c1\u30c9(\u4e0b\u8a18\u306e\u4f8b\u306fILGKFLHRL\uff09\u3060\u305d\u3046\u3067\u3059\u3002\u3053\u3093\u306a\u5c0f\u3055\u3044\u65ad\u7247\u3067\u30ad\u30e9\u30fcT\u7d30\u80de\u306e\u653b\u6483\u30dc\u30bf\u30f3\u3092\u62bc\u3057\u3066\u514d\u75ab\u53cd\u5fdc\u304c\u8d77\u3053\u305b\u308b\u306e\u306f\u9a5a\u304d\u3067\u3059\u3002
\nhttps:\/\/www.rcsb.org\/3d-view\/5MEO\/1
\nMHC\u5206\u5b50\u3068\u305d\u306e\u76f8\u624b\u3068\u306a\u308b\uff34\u7d30\u80de\u5074\u53d7\u5bb9\u4f53(T-Cell Receptor, TCR)\u3068\u3069\u306e\u304f\u3089\u3044\u5f37\u304f\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u306e\u304b\u3001\u8a08\u7b97\u4f8b\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u8abf\u3079\u305f\u3044\u3068\u3053\u308d\u3067\u3059\u3002
\nTCR\u306e\u69cb\u9020\u306f2019\u5e74\u306e\u5831\u544a\u304c\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u8f09\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u8ad6\u6587\uff08Nature573,546(2019)\uff09\u306e\u5f15\u7528\u3092\u8ffd\u3063\u304b\u3051\u308c\u3070\u8a08\u7b97\u3055\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u308f\u304b\u308a\u307e\u3059\u306d\u3002\u9762\u767d\u305d\u3046\u3067\u3059\u304c\u3001\u8ab0\u304b\u304c\u3084\u3063\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3002
\nhttps:\/\/www.rcsb.org\/3d-view\/6JXR\/1
\nMHC\u306b\u3064\u3044\u3066\u306e\u8aac\u660e\u306f\u4e0b\u8a18\u3092\u53c2\u8003\u306b\u3057\u307e\u3057\u305f\u3002
\nhttps:\/\/en.wikipedia.org\/wiki\/Major_histocompatibility_complex
\nhttps:\/\/en.wikipedia.org\/wiki\/MHC_class_I
\n\u203b\u3000\u30ad\u30e9\u30fcT\u7d30\u80de\u306e\u8a71\u306f\u3001\u4e88\u5b9a\u901a\u308a\u6765\u9031\u306b\u7d9a\u304d\u307e\u3059\u3002\u6297\u539f\u6c7a\u5b9a\u57fa\uff088\uff5e10\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\uff09\u306f\u4e88\u60f3\u3088\u308a\u3082\u5c0f\u3055\u3044\u3067\u3059\u306d\u3002\u7d30\u80de\u3092\u7834\u58ca\u3059\u308b\u653b\u6483\u306b\u4f7f\u3046\u5206\u5b50\u304c\u6c17\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n
\u82f1\u8a9e\u306f\u3000https:\/\/en.wikipedia.org\/wiki\/Major_histocompatibility_complex\u3000\u304b\u3089\u3002
\n\u201dThese genes are highly polymorphic, 19031 alleles of class I HLA, and 7183 of class II HLA are deposited for human in the IMGT database.\u201d
\ngene \u30b8\u30fc\u30f3\u3000\u907a\u4f1d\u5b50
\npolymorphic \u591a\u578b
\nalleles \u914d\u5ea7
\nHLA (human leukocyte antigen \u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09 = MHC (major histocompatibility complex \u4e3b\u8981\u7d44\u7e54\u9069\u5408\u6027\u8907\u5408\u4f53\uff09
\n\u201dMHC class I molecules are expressed in all nucleated cells and also in platelets\u2014in essence all cells but red blood cells.”
\nbe expressed \u767a\u73fe\u3057\u3066\u3044\u308b
\nnucleated cells \u6709\u6838\u7d30\u80de
\nplatelets \u8840\u5c0f\u677f
\nred blood cells = erithrocyte \u8d64\u8840\u7403\u3002\u6838\u304c\u306a\u3044\u3002
\n“It presents epitopes to killer T cells, also called cytotoxic T lymphocytes (CTLs).”
\nepitope \u30a8\u30d4\u30c8\u30fc\u30d7\u3000\uff1d\u3000\u6297\u539f\u6c7a\u5b9a\u57fa
\n\u201d A CTL expresses CD8 receptors, in addition to T-cell receptors (TCRs). When a CTL’s CD8 receptor docks to a MHC class I molecule, if the CTL’s TCR fits the epitope within the MHC class I molecule, the CTL triggers the cell to undergo programmed cell death by apoptosis.\u201d\u3000\u30ad\u30e9\u30fc\uff34\u7d30\u80de\u5074\u306eCD8\u53d7\u5bb9\u4f53\u304cMHC\u30af\u30e9\u30b9\uff29\u5206\u5b50\u306b\u9069\u5408\u3057\u305f\u3068\u304d\uff08\u2190\u81ea\u5206\u306e\u7d30\u80de\u3067\u3042\u308b\u3053\u3068\u3092\u8a8d\u8b58\uff09\u3001T\u7d30\u80de\u53d7\u5bb9\u4f53\u304c\u540c\u6642\u306b\u6297\u539f\u6c7a\u5b9a\u57fa\u306b\u9069\u5408\u3059\u308b\uff08\u2190\u305d\u306e\u7d30\u80de\u304c\u30ad\u30e9\u30fc\uff34\u7d30\u80de\u3092\u547c\u3073\u51fa\u3057\u305fB\u7d30\u80de\u3084\u6a39\u72b6\u7d30\u80de\u306b\u3059\u3067\u306b\u5206\u89e3\u3055\u308c\u3066\u3044\u3066\u30e4\u30d0\u3044\u7d30\u80de\u3067\u3042\u308b\uff09\u3068\u30ad\u30e9\u30fcT\u7d30\u80de\u306f\u76f8\u624b\u306e\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8d77\u52d5\u3059\u308b\uff08\u2192\u81ea\u7206\u30dc\u30bf\u30f3\u3092\u62bc\u3059\uff09\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u30d2\u30c8\u306e\u7d30\u80de\u306e\u8868\u9762\u306b\u306f\u3001\u81ea\u4ed6\u3092\u533a\u5225\u3057\u305f\u308a\u514d\u75ab\u7d30\u80de\u3068\u60c5\u5831\u3092\u3084\u308a\u53d6\u308a\u3059\u308b\u305f\u3081\u306b\u7cd6\u30bf\u30f3\u30d1\u30af\u304c\u3073\u3063\u3057\u308a\u751f\u3048\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u305d\u308c\u3092MHC\u3001\u5225\u540dHLA\u3068\u547c\u3073\u307e\u3059\u3002 https:\/\/ja.wikipedia.org\/wiki\/%E4%B8%BB%E8%A6%81%E7%B5%84%E7%B9%94%E9%81%A9%E5%90%88%E9%81%BA%E4%BC%9D%E5%AD%90%E8%A4%87%E5%90%88%E4%BD%93 MHC\u5206\u5b50\u306b\u306f\u591a\u304f\u306e\u578b\uff08\u5c11\u306a\u304f\u3068\u30822\u4e07\u4f59\uff09\u304c\u3042\u308a\u3001\uff11\u3064\u306e\u500b\u4f53\u306f\u7236\u6bcd\u304b\u3089\u53d7\u3051\u7d99\u3044\u3060\u591a\u6570\u306e\u578b\u3092\u540c\u6642\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u514d\u75ab\u7d30\u80de\u306f\u3053\u306e\u578b\u306e\u5206\u5e03\u3067\u81ea\u4ed6\u3092\u8b58\u5225\u3057\u3066\u304a\u308a\u3001\u81d3\u5668\u79fb…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[9],"class_list":["post-2149","post","type-post","status-publish","format-standard","hentry","category-bio","tag-bio"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2149"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2149\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}