\u5148\u9031\u306e\u56fd\u4f1a\u3067\u9ad8\u984d\u533b\u7642\u8cbb\u514d\u9664\u5236\u5ea6\u306e\u898b\u76f4\u3057\u306b\u3064\u3044\u3066\u8b70\u8ad6\u304c\u3042\u3063\u305f\u3088\u3046\u3067\u3059\u3002net\u60c5\u5831\u3057\u304b\u307f\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u9996\u76f8\u304c\u95a2\u9023\u3057\u3066CAR-T\u7d30\u80de\u6cbb\u7642\u306b\u8a00\u53ca\u3057\u305f\u3068\u306e\u3053\u3068\u3067\u3001\u3044\u3088\u3044\u3088\u3053\u306e\u6cbb\u7642\u6cd5\u304c\u672c\u683c\u7684\u306b\u5c0e\u5165\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3057\u3087\u3046\u3002CAR-T\u7d30\u80de\u6cbb\u7642\u306f\u304c\u3093\u306e\u514d\u75ab\u6cbb\u7642\u6cd5\u306e\u4e00\u3064\u3067\u3001\u60a3\u8005\u304b\u3089\u53d6\u308a\u51fa\u3057\u305f\u30ad\u30e9\u30fcT\u7d30\u80de\u3092\u907a\u4f1d\u5b50\u6539\u5909\u3057\u3066\u3001\u304c\u3093\u3092\u653b\u6483\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u3066\u304b\u3089\u6570\u767e\u4e07\u500b\u306b\u5897\u6b96\u3055\u305b\u3066\u60a3\u8005\u306b\u623b\u3059\u65b9\u6cd5\u3067\u3059\u3002\u514d\u75ab\u7cfb\u306e\u500b\u6027\u3084\u304c\u3093\u306e\u500b\u6027\u306e\u6761\u4ef6\u3092\u6e80\u305f\u305b\u3070\u5287\u7684\u306b\u52b9\u304f\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u30d2\u30c8\u306e\u5e73\u5747\u5bff\u547d\u3092\u6570\u5e74\u4ee5\u4e0a\u5ef6\u3070\u305b\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u500b\u4eba\u7684\u306b\u4e88\u60f3\u3057\u307e\u3059\u3002\u304c\u3093\u306e\u7a2e\u985e\u306f\u5c11\u306a\u304f\u3068\u3082\u6570\u5343\u4ee5\u4e0a\u3042\u308b\u3088\u3046\u306a\u306e\u3067\u3001\u3059\u3079\u3066\u306b\u5bfe\u5fdc\u3067\u304d\u308b\u307e\u3067\u306b\u306f\u76f8\u5f53\u6642\u9593\u304c\u304b\u304b\u308b\u3067\u3057\u3087\u3046\u304c\u3001\u7d20\u6674\u3089\u3057\u3044\u798f\u97f3\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u305f\u3060\u3057\u3001\u73fe\u5728\u306e\u3068\u3053\u308d1\u56de\u6570\u5343\u4e07\u5186\uff08\u60c5\u5831\u6e90\u306b\u3088\u3063\u30663000-8000\u4e07\u306e\u5e45\u304c\u3042\u308b\uff09\u304b\u304b\u308b\u3053\u3068\u3001\u3059\u3079\u3066\u306e\u304c\u3093\u306b\u5bfe\u5fdc\u3059\u308b\u3068\u6570\u4eba\u306b1\u4eba\u307e\u3067\u9069\u7528\u8005\u304c\u5897\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u307e\u307e\u9032\u3081\u308b\u3068\u533b\u7642\u8cbb\u5236\u5ea6\u3092\u7834\u58ca\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3059\u3002\u6c4e\u7528\u5316\u3059\u308b\u3068\u3044\u308d\u3044\u308d\u6280\u8853\u9769\u65b0\u304c\u8d77\u304d\u3066\u5024\u6bb5\u306f\u4e0b\u304c\u308b\u3068\u601d\u3044\u307e\u3059\u306e\u3067\u3057\u3070\u3089\u304f\u306e\u8f9b\u62b1\u3067\u3057\u3087\u3046\u3002\u4e0a\u624b\u304f\u52d5\u3044\u305f\u7b2c\u4e8c\u4e16\u4ee3CAR-T\u7d30\u80de\u306e\u767a\u660e\u8005\u306f\u4e00\u4eba\u3067\u3001\u7c73\u56fdUniversity of Pennsylvania \u306eCarl H. June\u6559\u6388\u3067\u3059\u3002\u4f55\u3082\u306a\u3051\u308c\u3070\u30ce\u30fc\u30d9\u30eb\u8cde\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u73fe\u5728\u3001\u540c\u5927\u306b\u306fCenter of Cellular Immunotherapy\u3068\u3044\u3046\u7814\u7a76\u6240\u304c\u3067\u304d\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.med.upenn.edu\/cci\/junelab\/
\n\u4eca\u9031\u306f\u3001\u3053\u306e\u6cbb\u7642\u6cd5\u3092\u3056\u3063\u3068\u898b\u3066\u304b\u3089\u3001\u30ad\u30e9\u30fcT\u7d30\u80de\u306e\u52d5\u4f5c\u6a5f\u69cb\u304c\u3069\u3053\u307e\u3067\u308f\u304b\u3063\u3066\u3044\u308b\u306e\u304b\u8abf\u3079\u3066\u3044\u3053\u3046\u3068\u601d\u3044\u307e\u3059\u3002\u60c5\u5831\u91cf\u304c\u591a\u3044\u306e\u3067\u30012\u9031\u9023\u7d9a\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n
\u82f1\u8a9e\u306f https:\/\/en.wikipedia.org\/wiki\/CAR_T_cell<\/p>\n
immunotherapy =immune+therapy\u3067\u3000\u514d\u75ab\u7642\u6cd5
\n\u201dIn biology, chimeric antigen receptors (CARs)\u2014also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors\u2014are receptor proteins that have been engineered to give T cells the new ability to target a specific antigen. The receptors are chimeric in that they combine both antigen-binding and T cell activating functions into a single receptor. \u201d
\nchimeric \u767a\u97f3\u306f\u30ab\u30a4\u300c\u30e1\u300d\u30ea\u30c3\u30af\u3001\u30ad\u300c\u30e1\u300d\u30ea\u30c3\u30af\u3000\u30ad\u30e1\u30e9\u306e\u3000\u30ad\u30e1\u30e9\u306f\u3001\u30e9\u30a4\u30aa\u30f3\u3068\u30e4\u30ae\u3068\u86c7\u304c\u5408\u4f53\u3057\u305f\u30ae\u30ea\u30b7\u30e3\u795e\u8a71\u306e\u602a\u7363\u3002\u8ee2\u3058\u3066\u3001\u7531\u6765\u306e\u9055\u3046\u90e8\u54c1\u304c\u304f\u3063\u3064\u3044\u3066\u3044\u308b\u3082\u306e\u3092\u6307\u3059\u3002CAR-T\u7d30\u80de\u3067\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u8868\u9762\u306e\u7cd6\u305f\u3093\u3071\u304f\u8cea\u3092\u8a8d\u8b58\u3059\u308b\u90e8\u5206\u3068\u3001\u30ad\u30e9\u30fcT\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3059\u308b\u90e8\u5206\u3002
\nchimera \u30ab\u30a4\u300c\u30e1\u300d\u30ea\u30a2\u3001\u30ad\u300c\u30df\u300d\u30a8\u30e9\u3000\u767a\u97f3\u6ce8\u610f\u3002\u3000\u30ad\u30e1\u30e9
\n“First, leukocytes are isolated using a blood cell separator in a process known as leukocyte apheresis. Peripheral blood mononuclear cells (PBMCs) are then separated and collected. The products of leukocyte apheresis are then transferred to a cell-processing center. In the cell processing center, specific T cells are stimulated so that they will actively proliferate and expand to large numbers.”
\nleukocytes \u767d\u8840\u7403
\nperipheral \u5468\u8fba\u306e\u3002peripheral blood \u3067\u672b\u68a2\u8840 \u3068\u8a33\u3057\u307e\u3059\u3002
\nmononuclear cells \u5358\u6838\u7d30\u80de\u3002\u3000\u8d64\u8840\u7403 erythrocyte \u306f\u7d30\u80de\u6838\u304c\u3042\u308a\u307e\u305b\u3093\u3002
\napheresis \u6210\u5206\u5206\u96e2\u3002\u3000\u6210\u5206\u732e\u8840\u306e\u9060\u5fc3\u5206\u96e2\u3092\u4f7f\u3046\u6280\u8853\u3067\u3059\u3002
\nproliferate \u5897\u6b96\u3059\u308b<\/p>\n","protected":false},"excerpt":{"rendered":"
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