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\nhttps:\/\/kokoro.squares.net\/
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\u82f1\u8a9e\u306f\u3000https:\/\/go.drugbank.com\/drugs\/DB14509
\n“Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects.”
\nmania\u3000\u8e81\u75c5
\na narrow therapeutic range \u6cbb\u7642\u306b\u4f7f\u3048\u308b\u7528\u91cf\u306f\u72ed\u3044\u3000\uff08\u591a\u3059\u304e\u308b\u3068\u6709\u6bd2\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\uff09
\nadverse effects \u60aa\u3044\u52b9\u679c
\n“Lithium’s therapeutic action may be due to a number of effects, ranging from inhibition of enzymes such as glycogen synthase kinase, inositol phosphatases, or modulation of glutamate receptors.”
\ninhibition \u6291\u6b62
\nenzyme \u300c\u30a8\u300d\u30f3\u30b6\u30a4\u30e0\u3000\u9175\u7d20
\nglutamate receptors \u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53
\n\u201dThe \u201cInositol depletion theory\u201d suggests lithium behaves as an uncompetitive inhibitor of inositol monophosphatase in a manner inversely proportional to the degree of stimulus. This inhibition lowers levels of inositol triphosphate6. However, stronger inhibitors of inositol monophosphatase are not as clinically effective and low levels of inositol triphosphate are associated with memory impairment.”
\nan uncompetitive inhibitor \u4e0d\u7af6\u5408\u963b\u5bb3\u5264\u3000\u9175\u7d20\u963b\u5bb3\u5264\u304c\u9175\u7d20\u3068\u57fa\u8cea\u3068\u306e\u9593\u3067\u5f62\u6210\u3055\u308c\u308b\u8907\u5408\u4f53\uff08E-S\u8907\u5408\u4f53\uff09\u306b\u306e\u307f\u7d50\u5408\u3059\u308b\u5834\u5408\u3092\u6307\u3057\u3001\u57fa\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u6642\u306b\u3088\u308a\u6a5f\u80fd\u3059\u308b\u3002
\nmemory impairment \u8a18\u61b6\u969c\u5bb3
\ninositol triphosphate \u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\uff13\u30ea\u30f3\u9178\uff1a\u3000\u91cd\u8981\u306a\u7d30\u80de\u5185\u4e8c\u6b21\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\u306e\uff11\u3064\u3067\u3059\u3002\u4e0b\u8a18\u53c2\u7167\u3002
\nhttps:\/\/bsd.neuroinf.jp\/wiki\/%E3%82%A4%E3%83%8E%E3%82%B7%E3%83%88%E3%83%BC%E3%83%AB1,4,5-%E4%B8%89%E3%83%AA%E3%83%B3%E9%85%B8<\/p>\n","protected":false},"excerpt":{"rendered":"
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