Human Cell Atlas\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u65e5\u672c\u306e\u6a5f\u95a2\u304b\u3089\u306e\u8ad6\u6587\u304c\u898b\u3048\u306a\u3044\u306e\u3067\u52dd\u624b\u306b\u5fc3\u914d\u3057\u3066\u3044\u307e\u3059\u3002\u4e0b\u8a18\u306b\u306f\u7406\u7814\u304cHuman Cell Atlas\u306e\uff14\u3064\u306e\u4e2d\u6838\u6a5f\u95a2\u306e\u4e00\u3064\u3068\u306a\u3063\u3066\u3044\u3066\u3001\u30a2\u30b8\u30a2\u4eba\u306b\u95a2\u3059\u308b\u89e3\u6790\u3092\u53d6\u308a\u307e\u3068\u3081\u308b\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304c\u30012017\u5e74\u306e\u8a71\u3067\u3059\u3002
\nhttps:\/\/www.riken.jp\/pr\/news\/2017\/171220_1\/
\n\u4e0b\u8a18\u306f\u5185\u95a3\u5e9c\u306e\u5831\u544a\u66f8\u3067\u3059\u304c\u3001\u4e88\u7b97\u304c\u8db3\u308a\u306a\u3055\u305d\u3046\u3067\u3059\u3002\u88c5\u7f6e\u306a\u3069\u304c\u5de8\u984d\u5316\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u751f\u7269\u3068\u60c5\u5831\u304c\u304b\u3089\u3093\u3067\u304f\u308b\u306e\u3067\u4e00\u4eba\u306ePI\uff08\u72ec\u7acb\u7814\u7a76\u8005\uff09\u3060\u3051\u3067\u306f\u56de\u305b\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u3001\u3068\u3044\u3046\u8a71\u3067\u3059\u3002\u88c5\u7f6e\u3092\u81ea\u56fd\u3067\u4f5c\u3063\u3066\u3044\u308c\u3070\u7a0e\u91d1\u3092\u6295\u5165\u3057\u3066\u3082\u3044\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u6d77\u5916\u3092\u6f64\u3059\u3060\u3051\u306a\u306e\u306f\u3061\u3087\u3063\u3068\u56f0\u308a\u307e\u3059\u306d\u3002
\nhttps:\/\/www8.cao.go.jp\/cstp\/gaiyo\/yusikisha\/20191031\/siryo2-2.pdf
\n\u4e0b\u8a18\u306f\u653f\u5e9c\u30b7\u30f3\u30af\u30bf\u30f3\u30af\u306eCRDS\u306e\u5831\u544a\u66f8\u3067\u3059\u3002\u751f\u7269\u3068\u7269\u7406\u306e\u4e21\u65b9\u3001\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304c\u3001\u7269\u7406\u3088\u308a\u3082\u60c5\u5831\u79d1\u5b66\u3060\u3068\u601d\u3044\u307e\u3059\uff08\u3053\u3053\u3067\u3044\u3046\u7269\u7406\u304c\u60c5\u5831\u79d1\u5b66\u3092\u542b\u3093\u3067\u3044\u308c\u3070\u3044\u3044\u306e\u3067\u3059\u304c\u30fb\u30fb\u30fb\uff09
\nhttps:\/\/www.jst.go.jp\/crds\/report\/CRDS-FY2020-WR-01.html
\n\u3069\u308c\u3082\u3061\u3087\u3063\u3068\u53e4\u3044\u60c5\u5831\u306a\u306e\u3067\u3001\u65e5\u672c\u306e\u8003\u3048\u308b\u7acb\u5834\u306e\u4eba\uff08\uff1d\u5927\u30dc\u30b9\u305f\u3061\u3001\u6614\u307b\u3069\u30ad\u30e3\u30e9\u304c\u7acb\u3063\u305f\u4eba\u304c\u3044\u306a\u3044\u611f\u3058\u3067\u3059\u304c\u2026\uff09\u304c\u4f55\u3092\u8003\u3048\u3066\u3044\u308b\u306e\u304b\u3001\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\u3092\u5f85\u3061\u305f\u3044\u3068\u3053\u308d\u3067\u3059\u3002Human Cell Atlas\u306e\u6210\u679c\u306f\u516c\u958b\u3055\u308c\u308b\u306e\u3067\uff08\uff1f\uff09\u3001\u672c\u5f53\u306b\u304a\u91d1\u304c\u52d5\u304f\u533b\u7642\u3084\u88fd\u85ac\u3078\u306e\u5fdc\u7528\u4ee5\u5916\u306f\u81ea\u5206\u3067\u3084\u3089\u306a\u304f\u3066\u3082\u3044\u3044\u3068\u601d\u3063\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u4e0b\u8a18\u30ec\u30d3\u30e5\u30fc\u306b\u3042\u308a\u307e\u3059\u304c\u3001\u5c11\u6570\u3057\u304b\u306a\u3044\u76ee\u7acb\u305f\u306a\u3044\u7d30\u80de\u304c\u898b\u3064\u304b\u308a\u96e3\u75c5\u3084\u304c\u3093\u306b\u95a2\u3059\u308b\u77e5\u898b\u304c\u8cea\u7684\u306b\u826f\u304f\u306a\u3063\u3066\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304c\u51fa\u3066\u304f\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002
\n\u82f1\u8a9e\u306f
\nhttps:\/\/www.nature.com\/articles\/s41591-022-02104-7
\n“Cell atlases provide a way to tackle each of these challenges (Fig. 1). In rare Mendelian genetic disorders, healthy tissue atlases have led to the discovery of novel cell types, including rare ones, that uniquely express key disease genes, and have even corrected long-held assumptions. ”
\ntackle \u30bf\u30c3\u30af\u30eb\u3059\u308b
\nMendelian \u30e1\u30f3\u30c7\u30eb\u7684
\nassumptions \u4eee\u5b9a
\n“For example, the pulmonary ionocyte \u2014 a novel, rare cell type discovered in cell atlases of the trachea \u2014 is the main cell type expressing CFTR, the causal gene in cystic fibrosis.”
\n\u65e5\u672c\u8a9e\u89e3\u8aac\u306f\u3000https:\/\/bio.nikkeibp.co.jp\/atcl\/report\/16\/011900001\/18\/08\/23\/00198\/
\npulmonary \u80ba\u306e
\ntrachea\u3000\u30c8\u30e9\u30ad\u30a2\u3000\u6c17\u7ba1
\nfibrosis \u7e4a\u7dad\u75c7
\n“In common complex diseases, similar analyses have related disease genes in associated loci to specific cell subsets across many inflammatory, autoimmune, neurodegenerative, respiratory, fibrotic and other diseases, using both healthy and disease atlases of the relevant tissue, and revealing novel unexpected associations. ”
\ninflammatory \u708e\u75c7\u6027\u306e
\nautoimmune \u81ea\u5df1\u514d\u75ab
\nneurodegenerative \u795e\u7d4c\u5909\u6027
\nrespiratory \u547c\u5438\u5668\u7cfb<\/p>\n","protected":false},"excerpt":{"rendered":"
Human Cell Atlas\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u65e5\u672c\u306e\u6a5f\u95a2\u304b\u3089\u306e\u8ad6\u6587\u304c\u898b\u3048\u306a\u3044\u306e\u3067\u52dd\u624b\u306b\u5fc3\u914d\u3057\u3066\u3044\u307e\u3059\u3002\u4e0b\u8a18\u306b\u306f\u7406\u7814\u304cHuman Cell Atlas\u306e\uff14\u3064\u306e\u4e2d\u6838\u6a5f\u95a2\u306e\u4e00\u3064\u3068\u306a\u3063\u3066\u3044\u3066\u3001\u30a2\u30b8\u30a2\u4eba\u306b\u95a2\u3059\u308b\u89e3\u6790\u3092\u53d6\u308a\u307e\u3068\u3081\u308b\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304c\u30012017\u5e74\u306e\u8a71\u3067\u3059\u3002 https:\/\/www.riken.jp\/pr\/news\/2017\/171220_1\/ \u4e0b\u8a18\u306f\u5185\u95a3\u5e9c\u306e\u5831\u544a\u66f8\u3067\u3059\u304c\u3001\u4e88\u7b97\u304c\u8db3\u308a\u306a\u3055\u305d\u3046\u3067\u3059\u3002\u88c5\u7f6e\u306a\u3069\u304c\u5de8\u984d\u5316\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u751f\u7269\u3068\u60c5\u5831\u304c\u304b\u3089\u3093\u3067\u304f\u308b\u306e\u3067\u4e00\u4eba\u306ePI\uff08\u72ec\u7acb\u7814\u7a76\u8005\uff09\u3060\u3051\u3067\u306f\u56de\u305b\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u3001\u3068\u3044\u3046\u8a71\u3067\u3059\u3002\u88c5\u7f6e\u3092\u81ea\u56fd\u3067\u4f5c\u3063\u3066\u3044\u308c\u3070\u7a0e\u91d1\u3092\u6295\u5165\u3057\u3066\u3082\u3044\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u6d77\u5916\u3092\u6f64\u3059\u3060\u3051\u306a\u306e…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46,52],"tags":[9,15],"class_list":["post-2089","post","type-post","status-publish","format-standard","hentry","category-bio","category-economics","tag-bio","tag-economics"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2089"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/2089\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}