\u751f\u7269\u304c\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u5fdc\u7b54\u3059\u308b\u3084\u308a\u65b9\u306b\u306f\u3001\u751f\u307e\u308c\u3064\u304d\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u3066\u3044\u308b\u3082\u306e\uff08\u672c\u80fd\uff09\u3068\u3001\u5f8c\u5929\u7684\u306b\u5b66\u7fd2\u3057\u305f\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u80fd\u304c\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u3069\u306e\u3088\u3046\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u8ad6\u6587\u306f\u3042\u307e\u308a\u591a\u304f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3044\u304f\u3064\u304b\u30bf\u30c0\u3067\u8aad\u3081\u308b\u89e3\u8aac\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002
\nhttps:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(13)00927-6
\n\u306b\u3088\u308c\u3070\u3001\u795e\u7d4c\u7d30\u80de(neuron)\u306b\u5bfe\u3059\u308bepigenetics\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002
\nepigenetics \u306f\u65e5\u672c\u8a9e\u3067\u306f\u300c\u5f8c\u6210\u907a\u4f1d\u5b66\u300d\u3068\u8a33\u3059\u3088\u3046\u3067\u3059\u304c\u3001DNA\u5869\u57fa\u914d\u5217\u306e\u5909\u5316\u3092\u3068\u3082\u306a\u308f\u306a\u3044\u304c\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u304c\u7d30\u80de\u5206\u88c2\u5f8c\u3082\u7d99\u627f\u3055\u308c\u308b\u73fe\u8c61\u306e\u7814\u7a76\u3001\u3060\u305d\u3046\u3067\u3059\u3002
\n\u30e1\u30c1\u30eb\u5316\u3084\u30a4\u30f3\u30c8\u30ed\u30f3\u3001\u30d2\u30b9\u30c8\u30f3\u306e\u69cb\u9020\u306a\u3069\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308aDNA\u914d\u5217\u3092\u5909\u3048\u305a\u306b\u305d\u306e\u767a\u73fe\u983b\u5ea6\u3092\u5909\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u6628\u65e5\u306esynaptic vecicle(\u30b7\u30ca\u30d7\u30b9\u5c0f\u80de\uff09\u306e\u8a71\u306b\u3064\u306a\u304c\u3063\u3066\u304d\u307e\u3059\u3002
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E3%82%A8%E3%83%94%E3%82%B8%E3%82%A7%E3%83%8D%E3%83%86%E3%82%A3%E3%82%AF%E3%82%B9
\n\u4e0a\u8a18\u8ad6\u6587\uff08\u5c55\u671b\u8a18\u4e8b perspective\uff09\u306b\u3088\u308b\u3068\u30012013\u5e74\u306e\u6bb5\u968e\u3067\u306f\u4e0b\u8a18\u306e\u3088\u3046\u306b\u307e\u3068\u3081\u3089\u308c\u307e\u3059\u3002
\n\u30fb\u5fc3\u7406\u7684\u30fb\u7269\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u3001\u30c8\u30e9\u30a6\u30de\u3001\u6bd2\u3001\u85ac\u7269\u3001\u751f\u80b2\u74b0\u5883\u306a\u3069\u306b\u3088\u3063\u3066\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u304a\u3051\u308bepigenetics\u306f\u5909\u5316\u3059\u308b
\n\u30fb\u305d\u306e\u5f71\u97ff\uff08\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\uff09\u306f\u7d99\u7d9a\u3057\u305f\u308a\u6c38\u7d9a\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3002
\n\u30fb\u3053\u308c\u304c\u795e\u7d4c\u7d30\u80de\u306b\u73fe\u308c\u308b\u3053\u3068\u306b\u3088\u308b\u8a18\u61b6\u3084\u5fdc\u7b54\u5909\u5316\u306a\u3069\u306f\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u6628\u65e5\u306e\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\u3084PTSD\u306b\u3082\u95a2\u4fc2\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u8aac\u304c\u6709\u529b\u3002
\n\u30fb\u3069\u306e\u3088\u3046\u306a\u6a5f\u69cb\u3067\u7279\u5b9a\u306e\u4f4d\u7f6e\u306e\u30b7\u30b9\u30c6\u30a4\u30f3\u304c\u30e1\u30c1\u30eb\u5316\u3055\u308c\u308b\u306e\u304b\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3002
\n\u30fb\u500b\u4f53\u5185\u3067\u6c38\u7d9a\u7684\u306aepigenetics\u5909\u5316\u304c\u5b50\u5b6b\u306b\u907a\u4f1d\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u8d77\u3053\u308b\u3001\u3068\u3044\u3046\u5b9f\u9a13\u7d50\u679c\u304c\u3042\u308b\u304c\u3001\u3069\u3053\u307e\u3067\u8d77\u3053\u308b\u304b\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3002
\n\u305d\u306e\u5f8c\u306e\u30ec\u30d3\u30e5\u30fc\u3092\u898b\u3064\u3051\u3089\u308c\u306a\u3044\u306e\u3067\u300110\u5e74\u305f\u3063\u3066\u3069\u3046\u306a\u3063\u305f\u304b\u306f\u4eca\u65e5\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u660e\u65e5\u8abf\u3079\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u3053\u3046\u3044\u3046\u6642\u306f\u3001\u3053\u306e\u8ad6\u6587\u3092\u5f15\u7528\u3057\u3066\u3044\u308b\u8ad6\u6587\uff08300\u500b\u3050\u3089\u3044\u3042\u308a\u307e\u3059\uff09\u3092\u7247\u3063\u7aef\u304b\u3089\u898b\u3066\u3044\u304f\u306e\u304c\u6709\u52b9\u3067\u3059\u3002\u307e\u305aabstract\u3092\u898b\u3066\u3001\u5fc5\u8981\u306a\u3089\u7cbe\u8aad\u3067\u3059\u3002
\n\u3053\u308c\u3092\u9ad8\u901f\u3067\u884c\u3046\u8a13\u7df4\u3092\u3059\u308b\u3068\u3001\u60c5\u5831\u53ce\u96c6\u306b\u95a2\u4fc2\u3059\u308b\u8077\u696d\uff08\u5b66\u8005\u4ee5\u5916\u306b\u3082\u3001\u7279\u8a31\u95a2\u4fc2\u306a\u3069\uff09\u306e\u8a13\u7df4\u3068\u3057\u3066\u6709\u52b9\u3067\u3059\u3002
\n\u30d5\u30a1\u30fc\u30d6\u30eb\u304c\u653b\u6483\u3057\u3066\u3044\u305f\u30e9\u30de\u30eb\u30af\u306e\u300c\u7528\u4e0d\u7528\u8aac\uff08\u7372\u5f97\u5f62\u8cea\u306e\u907a\u4f1d\uff09\u300d\u3068\u306e\u95a2\u4fc2\u3082\u6c17\u306b\u306a\u308b\u6240\u3067\u3059\u3002<\/p>\n
nature versus nurture\u3000\u81ea\u7136\u3068\u6559\u80b2\u3000\u3000nurture \u306f\u300c\u80b2\u6210\u300d\u300c\u306f\u3050\u304f\u307f\u300d
\n“it is now clear that experience, be it environmental toxins, maternal behavior, psychological or physical stress, learning, drug exposure, or psychotrauma, leads to active regulation of the chemical and three-dimensional structure of DNA in the nervous system, i.e., that experience regulates epigenetic mechanisms in the CNS”
\ntoxins \u6bd2
\nmaternal behavior \u6bcd\u6027\u306e\u3075\u308b\u307e\u3044
\n“These epigenomic changes lead to alterations in gene readout (and who knows what else?) in cells in the nervous system that trigger lasting, and in some cases perpetual, changes in neural function.”
\nlasting \u7d99\u7d9a\u3059\u308b
\nperpetual \u6c38\u7d9a\u3059\u308b
\n“Thus, several examples of the persisting CNS epigenomic effects on offspring of parental behavior and environmental insult have survived the rigors and skepticism of peer review”
\nCNS = central nerval system \u4e2d\u67a2\u795e\u7d4c\u7cfb
\noffspring \u5b50\u5b6b
\ninsult \u4fae\u8fb1
\nrigors \u53b3\u683c\u3055
\nskepticism\u3000\u61d0\u7591
\nof peer review \u8ad6\u6587\u67fb\u8aad\u306e
\n“The second flavor of transgenerational effect is the idea that experience-driven epigenetic changes in an animal might lead to heritable DNA methylation changes that are propagated through the germline through many or all subsequent generations. This neo-Lamarckian scenario is a truly frightening possibility, with interesting implications for topics such as free will, and is being hotly debated even as a possibility at present.”
\nflavor \u9999\u308a\u3001\u3067\u3059\u304c\u3001\u300c2\u756a\u76ee\u306e\u7279\u5fb4\u300d\u304f\u3089\u3044\u3067\u3057\u3087\u3046\u304b
\ntransgenerational\u3000\u4e16\u4ee3\u3092\u8d85\u3048\u305f
\nexperience-driven \u7d4c\u9a13\u306b\u8d77\u56e0\u3059\u308b
\nheritable \u7d99\u627f\u53ef\u80fd\u306a\u3001\u907a\u4f1d\u3059\u308b
\nfrightening possbility \u6050\u308b\u3079\u304d\u53ef\u80fd\u6027\u3001\u30e9\u30de\u30eb\u30af\u306e\u300c\u7372\u5f97\u5f62\u8cea\u306e\u907a\u4f1d\u300d\u306f\u73fe\u4ee3\u3067\u306f\u5426\u5b9a\u3055\u308c\u3066\u3044\u308b\u3001\u3068\u3044\u3046\u306e\u304c\u5b9a\u8aac\u3067\u3059\u304c\u3001\u7d4c\u9a13\u306b\u3088\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u304c\u907a\u4f1d\u3059\u308b\u3068\u3059\u308c\u3070\u3001\u3053\u308c\u304c\u8986\u308b\u306e\u3067\u3002
\nfree will \u81ea\u7531\u610f\u5fd7
\nneo-Lamarckian scenario\u3000\u65b0\u30e9\u30de\u30eb\u30af\u4e3b\u7fa9\u306e\u30b7\u30ca\u30ea\u30aa<\/p>\n","protected":false},"excerpt":{"rendered":"
\u751f\u7269\u304c\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u5fdc\u7b54\u3059\u308b\u3084\u308a\u65b9\u306b\u306f\u3001\u751f\u307e\u308c\u3064\u304d\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u3066\u3044\u308b\u3082\u306e\uff08\u672c\u80fd\uff09\u3068\u3001\u5f8c\u5929\u7684\u306b\u5b66\u7fd2\u3057\u305f\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u80fd\u304c\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u3069\u306e\u3088\u3046\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u8ad6\u6587\u306f\u3042\u307e\u308a\u591a\u304f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3044\u304f\u3064\u304b\u30bf\u30c0\u3067\u8aad\u3081\u308b\u89e3\u8aac\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002 https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(13)00927-6 \u306b\u3088\u308c\u3070\u3001\u795e\u7d4c\u7d30\u80de(neuron)\u306b\u5bfe\u3059\u308bepigenetics\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002 epigenetics \u306f\u65e5\u672c\u8a9e\u3067\u306f\u300c\u5f8c\u6210\u907a\u4f1d\u5b66\u300d\u3068\u8a33\u3059\u3088\u3046\u3067\u3059\u304c\u3001DNA\u5869\u57fa\u914d\u5217\u306e\u5909\u5316\u3092\u3068\u3082\u306a\u308f\u306a\u3044\u304c\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u304c\u7d30\u80de\u5206\u88c2\u5f8c\u3082\u7d99\u627f\u3055\u308c…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[9],"class_list":["post-1992","post","type-post","status-publish","format-standard","hentry","category-bio","tag-bio"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/1992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1992"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/1992\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}