https:\/\/www.nature.com\/articles\/s41467-018-06824-8
\n\u3092\u8aad\u3093\u3067\u307f\u307e\u3059\u3002\u3053\u306e\u8ad6\u6587\u306f\u3001”sweet bee”\uff08\u30b3\u30ca\u30ca\u30d0\u30c1?\uff09\u306e\u4ef2\u9593\u306e”L.albipes”\u3068\u3044\u3046\u7a2e\u306b\u306f\u5b64\u7acb\u3057\u305f\u751f\u6d3b\u3092\u9001\u308b\u30cf\u30c1\u3068\u5973\u738b\u30d0\u30c1\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u5de3\u3092\u3064\u304f\u308b\u30cf\u30c1\u306e\u4e8c\u7a2e\u985e\u304c\u3042\u308b\u3053\u3068\u306b\u6ce8\u76ee\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u884c\u3063\u3066\u9055\u3044\u3092\u898b\u305f\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002
\n\u305d\u306e\u7d50\u679c\u3001”syx1a”\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\uff17\u7a2e\u985e\u306e\u4e00\u5869\u57fa\u5909\u7570(SNP)\u304c\u3042\u308a\u3001\u5909\u7570\u306e\u6709\u7121\u3067syx1a\u306e\u767a\u73fe\u983b\u5ea6\u304c\u7570\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002syx1a\u306f\u30b7\u30ca\u30d7\u30b9\u5c0f\u80de\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3055\u3089\u306b\u9762\u767d\u3044\u306e\u306f\u3001\u30d2\u30c8\u306e\u81ea\u9589\u75c7\u306b\u3082\u540c\u69d8\u306e\u5909\u7570\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u7a2e\u3092\u307e\u305f\u3044\u3067\u3001\u793e\u4f1a\u6027\u306e\u5f37\u5f31\u306b\u5f37\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u306e\u304c\u7d50\u8ad6\u3067\u3059\u3002<\/p>\n
“Syx1a is critical for binding synaptic vesicles for their subsequent fusion and release of neurotransmitters at chemical synapses.”
\nsynapse \u30b7\u30ca\u30d7\u30b9\u3000\u795e\u7d4c\u7d30\u80de\u306e\u3064\u306a\u304e\u76ee\u3002\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\uff08\u7279\u5b9a\u306e\u5206\u5b50\uff09\u304c\u5c0f\u80de\u306b\u304f\u308b\u307e\u308c\u3066\u884c\u304d\u304b\u3046\u3002
\nneurotransmitters \u795e\u7d4c\u4f1d\u9054\u7269\u8cea
\nvecicle \u5c0f\u80de
\n“In honey bees, changes in syx1a protein expression are correlated with olfactory learning; in mice, syx1a knockouts show unusual social behaviors and deficits in synaptic plasticity and memory formation; and, in humans, syx1a has been repeatedly associated
\nwith ASD”
\nolfactory \u55c5\u899a
\nknockout \u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff08\u907a\u4f1d\u5b50\u5de5\u5b66\uff09\u3000\u907a\u4f1d\u5b50\u306e\u4e00\u90e8\u3092\u58ca\u3057\u3066\u767a\u73fe\u3057\u306a\u304f\u3059\u308b\u3053\u3068
\ndeficits \u6b20\u640d
\nASD = autism spectrum disorders \u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3
\nsolitary \u5b64\u7acb\u3057\u305f
\nsocial \u793e\u4f1a\u6027\u306e
\n“Specifically, the social allele drives higher expression of the reporter gene than the solitary allele (Tukey HSD, p < 0.0001), similar to the degree and direction we observed in the expression patterns of syx1a alleles in wildcaught social and solitary individuals”
\nallele \u5bfe\u7acb\u907a\u4f1d\u5b50
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E5%AF%BE%E7%AB%8B%E9%81%BA%E4%BC%9D%E5%AD%90
\nintron \u30a4\u30f3\u30c8\u30ed\u30f3\u3000\u8ee2\u5199\u306f\u3055\u308c\u308b\u304c\u6700\u7d42\u7684\u306b\u6a5f\u80fd\u3059\u308b\u8ee2\u5199\u7523\u7269\u304b\u3089\u306f\u9664\u304b\u308c\u308b\u5869\u57fa\u914d\u5217\u3002\u907a\u4f1d\u5b50\u2192\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7ffb\u8a33\u52b9\u7387\u3084\u6838\u304b\u3089\u904b\u3073\u51fa\u3059\u904e\u7a0b\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u983b\u5ea6\u3092\u5236\u5fa1\u3059\u308b\u6a5f\u80fd\u304c\u3042\u308b\u3002
\n\u3000\u53cd\u5bfe\u8a9e\u306f\u3000exon \u30a8\u30ad\u30bd\u30f3\u3001\u30a8\u30af\u30bd\u30f3
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E3%82%A4%E3%83%B3%E3%83%88%E3%83%AD%E3%83%B3
\nSNP\u3000\u30b9\u30cb\u30c3\u30d7\u3000\u3001single nucleotide polymorphism\u3000\u4e00\u3064\u3060\u3051\u5869\u57fa\u304c\u7570\u306a\u3063\u3066\u3044\u308b\u5909\u7570\uff08\u591a\u578b\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"
https:\/\/www.nature.com\/articles\/s41467-018-06824-8 \u3092\u8aad\u3093\u3067\u307f\u307e\u3059\u3002\u3053\u306e\u8ad6\u6587\u306f\u3001”sweet bee”\uff08\u30b3\u30ca\u30ca\u30d0\u30c1?\uff09\u306e\u4ef2\u9593\u306e”L.albipes”\u3068\u3044\u3046\u7a2e\u306b\u306f\u5b64\u7acb\u3057\u305f\u751f\u6d3b\u3092\u9001\u308b\u30cf\u30c1\u3068\u5973\u738b\u30d0\u30c1\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u5de3\u3092\u3064\u304f\u308b\u30cf\u30c1\u306e\u4e8c\u7a2e\u985e\u304c\u3042\u308b\u3053\u3068\u306b\u6ce8\u76ee\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u884c\u3063\u3066\u9055\u3044\u3092\u898b\u305f\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002 \u305d\u306e\u7d50\u679c\u3001”syx1a”\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\uff17\u7a2e\u985e\u306e\u4e00\u5869\u57fa\u5909\u7570(SNP)\u304c\u3042\u308a\u3001\u5909\u7570\u306e\u6709\u7121\u3067syx1a\u306e\u767a\u73fe\u983b\u5ea6\u304c\u7570\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002syx1a\u306f\u30b7\u30ca\u30d7\u30b9\u5c0f\u80de…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[9],"class_list":["post-1991","post","type-post","status-publish","format-standard","hentry","category-bio","tag-bio"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/1991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1991"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/1991\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}