{"id":1974,"date":"2024-06-04T00:00:00","date_gmt":"2024-06-04T00:00:00","guid":{"rendered":"urn:uuid:974d6b9d-b60c-4d96-b127-b0bdc18033ad"},"modified":"2024-06-04T00:00:00","modified_gmt":"2024-06-04T00:00:00","slug":"tang-niao-bing-zhi-liao-yao-jian-yaseyao-glp-1lei-si-ti","status":"publish","type":"post","link":"https:\/\/www.sekaiken.com\/?p=1974","title":{"rendered":"\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac \u517c \u3084\u305b\u85ac GLP-1\u985e\u4f3c\u4f53"},"content":{"rendered":"<p>GLP-1\u3068\u3044\u3046\u30a2\u30df\u30ce\u917830\u500b\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u3042\u3063\u3066\u3001\u305d\u306e\u985e\u4f3c\u4f53\u304c\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u30fb\u517c\u30fb\u3084\u305b\u85ac\u3068\u306a\u308a\u307e\u3059\u3002<br \/>\n\u69cb\u9020\u304c\u4e0b\u8a18\u306eFig.2\u306b\u51fa\u3066\u3044\u307e\u3059\u3002<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"X1moytOWXl\"><p><a href=\"https:\/\/observatoireprevention.org\/en\/2023\/03\/02\/ozempic-semaglutide-and-mounjaro-tirzepatide-a-major-breakthrough-for-the-treatment-of-obesity\/\">Ozempic\u00ae (semaglutide) and Mounjaro\u2122 (tirzepatide), a major breakthrough for the treatment of obesity<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Ozempic\u00ae (semaglutide) and Mounjaro\u2122 (tirzepatide), a major breakthrough for the treatment of obesity&#8221; &#8212; Observatoire de la pr\u00e9vention de l&#039;Institut de Cardiologie de Montr\u00e9al\" src=\"https:\/\/observatoireprevention.org\/en\/2023\/03\/02\/ozempic-semaglutide-and-mounjaro-tirzepatide-a-major-breakthrough-for-the-treatment-of-obesity\/embed\/#?secret=w195OKLSp8#?secret=X1moytOWXl\" data-secret=\"X1moytOWXl\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><br \/>\nNovo Nordisk\u793e\uff08\u30ce\u30dc\u30ce\u30eb\u30c7\u30a3\u30b9\u30af\u3001\u30c7\u30f3\u30de\u30fc\u30af\uff09\u306esemaglutide\u306fGLP-1\u306e\u30a2\u30df\u30ce\u9178\u304c\uff12\u3064\u5909\u3048\u3066\u3042\u3063\u3066\u3001\u9014\u4e2d\u306b\u30a2\u30eb\u30ad\u30eb\u9396\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002Eli-Lilly\u793e\uff08\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u3001\u82f1\u56fd\uff09\u306eTirzepatide\u306f\u3001GLP-1\u306e\u30a2\u30df\u30ce\u9178\u3092\uff14\u3064\u5909\u3048\u305f\u3082\u306e\u3068\u3001\u3082\u3046\u4e00\u3064\u306eGIP\u3068\u3044\u3046\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u90e8\u306e\u69cb\u9020\u3068\u985e\u4f3c\u3057\u305f\u90e8\u5206\u3092\u5408\u4f53\u3055\u305b\u3066\u3042\u308a\u3001\u3055\u3089\u306b\u30a2\u30eb\u30ad\u30eb\u9396\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3053\u306e\u30a2\u30df\u30ce\u9178\u306e\u6539\u5909\u3068\u30a2\u30eb\u30ad\u30eb\u9396\u304c\u751f\u4f53\u3092\u3060\u307e\u3057\u3066\u85ac\u306b\u306a\u308b\u4f5c\u7528\u3092\u4f5c\u3063\u3066\u3044\u308b\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u305f\u304f\u3055\u3093\u8a66\u3057\u305f\u306e\u3067\u3057\u3087\u3046\u306d\u3002\u30a2\u30eb\u30ad\u30eb\u9396\u3092\u4ed8\u3051\u305f\u7406\u7531\u3084\u306a\u305c\u3053\u306e\u5834\u6240\u304b\u304c\u8208\u5473\u6df1\u3044\u3067\u3059\u3002<br \/>\nGLP-1\u306f\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u985e\u4f3c\u30da\u30d7\u30c1\u30c9(glucagon-like peptide)-1 \u306e\u7565\u3067\u300130\u500b\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002L\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u305d\u3046\u3067\u3059\u3002<br \/>\nGIP\u306f\u3001glucose-dependent insulinotropic polypeptide\u306e\u7565\u3067\u300142\u500b\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002K\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u305d\u3046\u3067\u3059\u3002<br \/>\n\u30b0\u30eb\u30ab\u30b4\u30f3\u3001K\u7d30\u80de\u3001L\u7d30\u80de\u306a\u3069\u3088\u304f\u308f\u304b\u3089\u306a\u3044\u306e\u3067\u8abf\u3079\u307e\u3057\u305f\u3002\u30b0\u30eb\u30ab\u30b4\u30f3\u306f\u4eba\u306e\u4f53\u3067\u4f5c\u3089\u308c\u308b\u8840\u7cd6\u5024\u3092\u4e0a\u3052\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3001\u81b5\u81d3\u306e\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u5cf6\u306e\u03b1\u7d30\u80de\u304b\u3089\u4f5c\u3089\u308c\u307e\u3059\u3002<br \/>\nK\u7d30\u80de\u3068L\u7d30\u80de\u306f\u8178\u306b\u3042\u308b\u5185\u5206\u6ccc\u7d30\u80de\u3067\u3001K\u7d30\u80de\u304c\u4e0a\u90e8\u5c0f\u8178\uff08\u5341\u4e8c\u6307\u8178\u3001\u7a7a\u8178\uff09\u306b\u5206\u5e03\u3057\u3066GIP\u3092\u7523\u51fa\u3001L\u7d30\u80de\u306f\u4e0b\u90e8\u5c0f\u8178\u3068\u5927\u8178\u306b\u5206\u6ccc\u3057\u3066GLP-1\u3092\u7523\u51fa\u3059\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002<br \/>\n\u3069\u3061\u3089\u3082\u81b5\u81d3\u306e\u03b2\u7d30\u80de\uff08\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u3092\u4f5c\u308b\uff09\u306e\u5c02\u7528\u306e\u53d7\u5bb9\u4f53\u3092\u901a\u3058\u3066\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u306e\u5206\u6ccc\u3092\u8abf\u7bc0\u3059\u308b\u305d\u3046\u3067\u3059\u304c\u3001\u8840\u7cd6\u5024\u304c\u4f4e\u3044\u6642\u306f\u50cd\u304b\u306a\u3044\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u4f4e\u8840\u7cd6\u306e\u526f\u4f5c\u7528\u304c\u51fa\u306b\u304f\u3044\u85ac\u306b\u306a\u308b\u305d\u3046\u3067\u3059\u3002<br \/>\n\u98df\u5f8c\u306b\u8178\u304c\u7cd6\u5206\u3092\u5438\u53ce\u3059\u308b\u3068\u305d\u306e\u60c5\u5831\u3092\u81b5\u81d3\u306b\u9001\u3063\u3066\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u3092\u51fa\u3059\u308f\u3051\u3067\u3059\u304c\u3001\u30d6\u30c9\u30a6\u7cd6\u306e\u8840\u4e2d\u6fc3\u5ea6\u3060\u3051\u3067\u306a\u304f\u3001\u8178\u304b\u3089\u306e\u4fe1\u53f7\u304c\u8907\u6570\u3042\u308b\u306e\u306f\u9762\u767d\u3044\u3067\u3059\u306d\u3002\u7cd6\u5c3f\u75c5\u306f\u30d6\u30c9\u30a6\u7cd6\u6fc3\u5ea6\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u60aa\u304f\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u308c\u4ee5\u5916\u306e\u5236\u5fa1\u6cd5\u3092\u8a66\u3057\u305f\u3089\u3046\u307e\u304f\u3044\u3063\u305f\u308f\u3051\u3067\u3059\u306d\u3002<br \/>\n\u4e0b\u8a182019\u5e74\u306e\u89e3\u8aac\u304c\u308f\u304b\u308a\u3084\u3059\u304b\u3063\u305f\u3067\u3059\u3002<br \/>\nhttps:\/\/www.jstage.jst.go.jp\/article\/naika\/108\/9\/108_1713\/_pdf<br \/>\n\u30cb\u30e5\u30fc\u30b9\u3092\u3044\u308d\u3044\u308d\u8aad\u3080\u3068\u5f8c\u767a\u306eTirzepatide\u306fGLP-1\u3068GIP\u306e\u4e21\u65b9\u306e\u53d7\u5bb9\u4f53\u306b\u50cd\u304d\u3001\u3088\u308a\u5f37\u529b\u306a\u300c\u3084\u305b\u85ac\u300d\u3068\u3057\u3066\u306e\u4f5c\u7528\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u3069\u3046\u3044\u3046\u6a5f\u69cb\u306a\u306e\u304b\u6c17\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\nsemaglutide, tirzepatide\u306f\u3084\u305b\u85ac\u3068\u3057\u3066\u306e\u9700\u8981\u304c\u9ad8\u3059\u304e\u3066\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u624b\u306b\u5165\u3089\u306a\u3044\u3068\u3044\u3046\u306e\u304c\u6628\u5e74\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u82f1\u8a9e\u306f\u3001\u3000https:\/\/en.wikipedia.org\/wiki\/Glucagon\u3000\u304b\u3089\u3002<br \/>\n&ldquo;Glucagon is a 29-amino acid polypeptide.Glucagon is a peptide (nonsteroid) hormone&rdquo;<br \/>\n\u3000\u203b\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u3067\u306a\u3044\u30db\u30eb\u30e2\u30f3\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002\u7a2e\u985e\u306f\uff12\u3064\u306e\u3069\u3061\u3089\u304b\u3057\u304b\u306a\u3044\u306e\u304b\u3001\u6c17\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\n&ldquo;The hormone is synthesized and secreted from alpha cells (\u03b1-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas. &rdquo;<br \/>\nhormone \u30db\u30eb\u30e2\u30f3<br \/>\nsecrete \u30bb\u30af\u300c\u30ea\u300d\u30fc\u30c8\u3000\u5206\u6ccc\u3059\u308b<br \/>\nthe islet of Langerhans \u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u5cf6<br \/>\nendocrine\u3000\u300c\u30a8\u300d\u30f3\u30c9\u30af\u30ea\u30f3\u3000\u5185\u5206\u6ccc\u306e<br \/>\nportion \u90e8\u5206<br \/>\npancreas \u81b5\u81d3<br \/>\n&ldquo;In 1922, C. Kimball and John R. Murlin identified a component of pancreatic extracts responsible for this blood sugar increase, terming it &ldquo;glucagon&rdquo;, a portmanteau of &ldquo;glucose agonist&rdquo;.[6][33] In the 1950s, scientists at Eli Lilly isolated pure glucagon, crystallized it, and determined its amino acid sequence.<br \/>\nidentify \u540c\u5b9a\u3059\u308b\u3002\u4f55\u304b\u3092\u3069\u3093\u3074\u3057\u3083\u308a\u3067\u5f53\u3066\u308b\u3068\u304d\u306f\u3000identify\u304c\u4f7f\u3048\u307e\u3059\u3002<br \/>\nextracts \u62bd\u51fa\u7269<br \/>\nportmanteau\u3000\u30dd\u30fc\u30c8\u300c\u30de\u300d\u30f3\u30c8\u30a6\u3000\u4e21\u958b\u304d\u306e\u65c5\u884c\u9784(\u30d5\u30e9\u30f3\u30b9\u8a9e)\u3001\u8ee2\u3058\u3066\u300c\uff12\u3064\u306e\u5358\u8a9e\u3092\u5408\u308f\u305b\u305f\u3082\u306e\u300d\u3000\u3000\u4f8b\u3000&lsquo;Brunch&rsquo; is a well-known portmanteau.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>GLP-1\u3068\u3044\u3046\u30a2\u30df\u30ce\u917830\u500b\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u3042\u3063\u3066\u3001\u305d\u306e\u985e\u4f3c\u4f53\u304c\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u30fb\u517c\u30fb\u3084\u305b\u85ac\u3068\u306a\u308a\u307e\u3059\u3002 \u69cb\u9020\u304c\u4e0b\u8a18\u306eFig.2\u306b\u51fa\u3066\u3044\u307e\u3059\u3002 Ozempic\u00ae (semaglutide) and Mounjaro\u2122 (tirzepatide), a major breakthrough for the treatment of obesity Novo Nordisk\u793e\uff08\u30ce\u30dc\u30ce\u30eb\u30c7\u30a3\u30b9\u30af\u3001\u30c7\u30f3\u30de\u30fc\u30af\uff09\u306esemaglutide\u306fGLP-1\u306e\u30a2\u30df\u30ce\u9178\u304c\uff12\u3064\u5909\u3048\u3066\u3042\u3063\u3066\u3001\u9014\u4e2d\u306b\u30a2\u30eb\u30ad\u30eb\u9396\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002Eli-Lilly\u793e\uff08\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u3001\u82f1\u56fd\uff09\u306eTirzepatide\u306f\u3001GLP-1\u306e\u30a2\u30df&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[46],"tags":[9],"class_list":["post-1974","post","type-post","status-publish","format-standard","hentry","category-bio","tag-bio"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/1974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1974"}],"version-history":[{"count":0,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=\/wp\/v2\/posts\/1974\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sekaiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}