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\nhttps:\/\/seikagaku.jbsoc.or.jp\/index.html?vol=93&no=5
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\nhttps:\/\/www.idac.tohoku.ac.jp\/site_ja\/
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\u82f1\u8a9e\u306f\u3001https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10522965\/ \u304b\u3089
\n“…the alkyl hydropersulfide (RSSH) functional group is a superior nucleophile compared to the corresponding thiol (RSH) due to the alpha effect. However, recent quantum mechanical calculations and experimental data show that persulfides are not \u201csuper\u201d nucleophiles, but rather potent electrophiles in cellular biology. ”
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\nelectrophile \u30a8\u300c\u308c\u300d\u30af\u30c8\u30ed\u30d5\u30a1\u30a4\u308b\u3000\u6c42\u96fb\u5b50\u8a66\u85ac\uff08\u540c\u3001\uff0d\u96fb\u8377\u3068\u53cd\u5fdc\u3059\u308b\u5206\u5b50\uff09
\ncellular biology \u7d30\u80de\u751f\u7269\u5b66\u3000\u3000cf cellular phone \u30bb\u30eb\u30e9\u30fc\u30d5\u30a9\u30f3\u3000\u5c0f\u7bc4\u56f2\u3092\u30ab\u30d0\u30fc\u3059\u308b\u591a\u6570\u306e\u57fa\u5730\u5c40\u3092\u4f7f\u3063\u305f\u73fe\u5728\u306e\u643a\u5e2f\u96fb\u8a71\u3002\u7d30\u80de\u304c\u304f\u3063\u3064\u3044\u3066\u7d44\u7e54\u3092\u4f5c\u308b\u3088\u3046\u306a\u30a4\u30e1\u30fc\u30b8\u3067\u540d\u3065\u3051\u3089\u308c\u305f\u3002
\n“It is proposed here that persulfides, via their electrophilic signalling effects, induces a cellular hormesis effect, which may explain the observed effects of altered RSSH production.”
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\n\u3000“In the fields of biology and medicine hormesis is defined as an adaptive response of cells and organisms to a moderate (usually intermittent) stress. Examples include ischemic preconditioning, exercise, dietary energy restriction and exposures to low doses of certain phytochemicals.”
\nadaptive response \u9069\u5fdc\u7684\u306a\u5fdc\u7b54
\nmoderate \u9069\u5ea6\u306a
\nintermittent \u9593\u6b20\u7684\u306a
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\n“when excess, exogenous H2S is administered”
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\nexogenous \u5916\u6765\u6027\u306e
\nadminister \u7ba1\u7406\u3059\u308b\u3001\u6295\u4e0e\u3059\u308b<\/p>\n","protected":false},"excerpt":{"rendered":"
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