\u30a2\u30ec\u30eb\u30ae\u30fc\u95a2\u4fc2\u3067\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u4f4e\u5206\u5b50\u306f\u30d2\u30b9\u30bf\u30df\u30f3\uff08C5H9N3\uff09\u3067\u3057\u3087\u3046\u3002\u3053\u308c\u306fI\u578b\u30a2\u30ec\u30eb\u30ae\u30fc\u3067\u767b\u5834\u3059\u308b\u5373\u52b9\u6027\u306e\u7269\u8cea\u3067\u3001\u8541\u9ebb\u75b9\uff08\u3058\u3093\u307e\u3057\u3093\uff09\u3001\u304b\u3086\u307f\u3001\u8840\u7ba1\u900f\u904e\u6027\u306e\u4ea2\u9032\uff08\u9f3b\u6c34\uff09\u3001\u5e73\u6ed1\u7b4b\u53ce\u7e2e\uff08\u6c17\u9053\u3067\u304a\u3053\u308b\u3068\u5598\u606f\u3001\u8178\u3067\u8d77\u3053\u308b\u3068\u8179\u75db\u30fb\u4e0b\u75e2\uff09\u306a\u3069\u3092\u8a98\u767a\u3057\u307e\u3059\u3002
\nhttps:\/\/en.wikipedia.org\/wiki\/Histamine
\n\u30d2\u30b9\u30bf\u30df\u30f3\u306f\u6297\u539f\u304c\u4f53\u5185\u306b\u4fb5\u5165\u3057\u305f\u6642\u306b\u30ea\u30f3\u30d1\u7403\u306e\u4e00\u7a2e\u3067\u3042\u308bB\u7d30\u80de\u304c\u5206\u5316\u3057\u305f\u5f62\u8cea\u7d30\u80de\u304b\u3089\u3064\u304f\u3089\u308c\u308bIgE(\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3E)\u304c\u6297\u539f\u3092\u4f34\u3063\u3066\u7d44\u7e54\u4e2d\u306e\u30de\u30b9\u30c8\u7d30\u80de\u3084\u8840\u6db2\u4e2d\u306e\u597d\u5869\u57fa\u7403\u306b\u7d50\u5408\u3057\u305f\u6642\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u540c\u6642\u306b\u4ed6\u306e\u4fe1\u53f7\u4f1d\u9054\u7269\u8cea\u3082\u653e\u51fa\u3055\u308c\u3001\u3055\u307e\u3056\u307e\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u95a2\u9023\u304c\u6df1\u3044\u306e\u306f\u597d\u9178\u7403\u306e\u6d3b\u6027\u5316\u3067\u3001\u3053\u308c\u306b\u3088\u308a\u4f53\u304c\u6301\u7d9a\u7684\u306b\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u8d77\u3053\u3057\u307e\u3059\uff08\u9045\u5ef6I\u578b\u2192IV\u578b\uff09\u3002\u9762\u767d\u3044\u306e\u306f\u3001IgE\u306f\u54fa\u4e73\u985e\u306b\u3057\u304b\u5b58\u5728\u305b\u305a\u3001\u73fe\u4ee3\u3067\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u3044\u3046\u60aa\u3044\u50cd\u304d\u3057\u304b\u6301\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u597d\u9178\u7403\u304c\u5bc4\u751f\u866b\uff08\u56de\u866b\u3001\u4f4f\u8840\u5438\u866b\u306a\u3069\uff1a\u307e\u3068\u3081\u3066\u305c\u3093\u866b\u985e\uff09\u306e\u795e\u7d4c\u7cfb\u3092\u9ebb\u75fa\u3055\u305b\u308b\u7269\u8cea\u3092\u653e\u51fa\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u5bc4\u751f\u866b\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u3068\u3057\u3066\u9032\u5316\u3057\u305f\u3068\u3044\u3046\u306e\u304c\u5b9a\u8aac\u306e\u3088\u3046\u3067\u3059\u3002\u307e\u305f\u3001\u4e0b\u8a18\u306b\u3088\u308b\u3068\u30cf\u30c1\u3084\u86c7\u306e\u6bd2\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u306b\u3082\u5f79\u7acb\u3063\u3066\u3044\u308b\u3068\u306e\u3053\u3068\u3067\u3059(2013\u5e74)\u3002
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E5%85%8D%E7%96%AB%E3%82%B0%E3%83%AD%E3%83%96%E3%83%AA%E3%83%B3E
\n\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u3067\u3088\u304f\u4f7f\u308f\u308c\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u306f\u3001\u597d\u9178\u7403\u306e\u6d3b\u6027\u5316\u3092\u6b62\u3081\u308b\u50cd\u304d\u3060\u305d\u3046\u3067\u3059\u3002<\/p>\n
asthma \u30a2\u305a\u30de\u3000\u5598\u606f
\nurticaria, hives \u8541\u9ebb\u75b9\u3000\u30cf\u30a4\u30f4\u30ba\u3000level 8
\nitching \u304b\u3086\u307f
\nIgE = immunoglobulin E \u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3E
\nabdominal pain \u30a2\u30d6\u300c\u30c9\u300d\u30df\u30ca\u308b\u3000\u8179\u75db
\nlymphocyte \u300c\u308a\u300d\u30f3\u30d5\u30a9\u30b5\u30a4\u30c8\u3000\u30ea\u30f3\u30d1\u7403
\nparasite \u5bc4\u751f\u866b
\nsmooth muscle \u5e73\u6ed1\u7b4b
\nstriated muscle \u6a2a\u7d0b\u7b4b\u3000\u30b9\u30c8\u30ea\u30a8\u30a4\u30c6\u30c3\u30c9\u306f\u3001\u300c\u3059\u3058\u304c\u3064\u3044\u305f\u300d\u3000striation \u306f\u5b9d\u77f3\u3084\u4eba\u5de5\u7d50\u6676\u3067\u300c\u3059\u3058\u300d\u304c\u5165\u3063\u3066\u3044\u308b\u3053\u3068\u3002
\nintestine \u30a4\u30f3\u300c\u30c6\u300d\u30b9\u30c6\u30a3\u30f3\u3000\u8178 level 9
\ngut \u30ac\u30c3\u30c8\u3000\u8178(\u306f\u3089\u308f\u305f\uff09\u3001\u30ac\u30c3\u30c4\u3001\u30c6\u30cb\u30b9\u30e9\u30b1\u30c3\u30c8\u3084\u30d0\u30a4\u30aa\u30ea\u30f3\u306e\u7d43\u3001\u809d\u5fc3\u306a\u3068\u3053\u308d
\ndiarrhea \u30c0\u30a4\u30a2\u300c\u30ea\u300d\u30fc\u30a2\u3000\u3000\u4e0b\u75e2 level 10
\nincreased vascular permeability \u8840\u7ba1\u900f\u904e\u6027\u306e\u4ea2\u9032
\nrunny nose \u9f3b\u6c34
\nmammals \u54fa\u4e73\u985e
\nvenom \u300c\u30f4\u30a3\u300d\u30fc\u30ce\u30e0\u3000\u86c7\u306a\u3069\u306e\u6bd2
\ndifferentiate \u5206\u5316\u3059\u308b
\nparalyze \u9ebb\u75fa\u3055\u305b\u308b<\/p>\n
\u203b DeepL\u306e\u7ffb\u8a33\u3092\u8f09\u305b\u3066\u307f\u307e\u3059\u3002\u79c1\u306f\u3053\u306e\u8a33\u306b\u7d76\u5bfe1\u5206\u4ee5\u4e0a\u304b\u304b\u308a\u307e\u3059\u304c\u3001DeepL\u306f1\u79d2\u3067\u3059\u3002
\nThe best known small molecule in allergy is probably histamine (C5H9N3). This is a fast-acting substance that appears in type I allergies and induces urticaria (hives), itching, increased vascular permeability (runny nose), and smooth muscle contractions (asthma in the airways, abdominal pain and diarrhea in the gut).
\nhttps:\/\/en.wikipedia.org\/wiki\/Histamine
\nHistamine is released when IgE (immunoglobulin E), which is produced by differentiated plasma cells of B cells, a type of lymphocyte, when antigen invades the body, binds to mast cells in tissues and basophils in the blood with the antigen. At the same time, other signaling molecules are also released, triggering a variety of allergic reactions. Of these, the most relevant to allergy is the activation of eosinophils, which causes the body to become persistently allergic (delayed type I \u2192 type IV). Interestingly, IgE exists only in mammals and has only the bad function of allergy in modern times, but the theory seems to be that it evolved as a defense against parasites because eosinophils release a substance that paralyzes the nervous system of parasites (e.g., roundworms, blood-sucking worms: collectively, the astroturf). They also serve as a defense against bee and snake venom, according to (2013).Steroids, which are commonly used in allergy treatment, are said to work by stopping the activation of eosinophils.<\/p>\n","protected":false},"excerpt":{"rendered":"
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