{"id":1580,"date":"2022-11-03T00:00:00","date_gmt":"2022-11-03T00:00:00","guid":{"rendered":"urn:uuid:cd8160d3-4638-469a-a83e-739e08152d91"},"modified":"2022-11-03T00:00:00","modified_gmt":"2022-11-03T00:00:00","slug":"hurionyan-jiu-niokerushi-gu","status":"publish","type":"post","link":"https:\/\/www.sekaiken.com\/?p=1580","title":{"rendered":"\u30d7\u30ea\u30aa\u30f3\u7814\u7a76\u306b\u304a\u3051\u308b\u4e8b\u6545"},"content":{"rendered":"<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u304c\u7570\u5e38\u306b\u306a\u3063\u3066\u305d\u308c\u304c\u611f\u67d3\u3059\u308b\u3068\u3044\u3046\u30d7\u30ea\u30aa\u30f3\u75c5\u306f\u4e0d\u601d\u8b70\u306a\u3053\u3068\u304c\u591a\u304f\u3001\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u591a\u6b21\u5143NMR\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5404\u90e8\u5206\u306e\u8ddd\u96e2\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u5f62\u72b6\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u305d\u306e\u5b9f\u9a13\u3068\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6628\u5e74\u767a\u8868\u306e\u7814\u7a76\u306a\u3069\u306f\u9762\u767d\u3044\u3067\u3059\u3002\u307e\u308c\u306a\u904e\u7a0b\u306e\u52b9\u7387\u7684\u306a\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u4f8b\uff08metadynamics\u3001\u3044\u305a\u308c\u89e3\u8aac\u3057\u307e\u3057\u3087\u3046)\u3068\u3057\u3066\u52c9\u5f37\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\nhttps:\/\/www.pnas.org\/doi\/10.1073\/pnas.2019631118<br \/>\n\u3053\u306e\u8ad6\u6587\u3067\u306f\u30d7\u30ea\u30aa\u30f3\u306e\u65ad\u7247\u3092\u6271\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u65ad\u7247\u306a\u3089\u3070\u75c5\u539f\u6027\u306f\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u9ec4\u71b1\u75c5\u306e\u7814\u7a76\u306a\u3069\u3067\u3082\u91ce\u53e3\u82f1\u4e16\u535a\u58eb\u3092\u306f\u3058\u3081\u3068\u3057\u3066\u591a\u304f\u306e\u72a0\u7272\u304c\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u8abf\u7406\u3057\u3066\u3082\u611f\u67d3\u6027\u304c\u5931\u308f\u308c\u306a\u3044\u3068\u3044\u3046\u30d7\u30ea\u30aa\u30f3\u306f\u6050\u308d\u3057\u3044\u3067\u3059\uff08135\u2103\u4ee5\u4e0a\u306e\u6c34\u84b8\u6c17\u51e6\u7406\u304b\u5869\u7d20\u7cfb\u85ac\u5264\u307e\u305f\u306f2M NaOH\u304c\u5fc5\u8981\u3068\u306e\u3053\u3068\uff09\u3002\u8abf\u3079\u3066\u3044\u305f\u3089\u3084\u306f\u308a\u4e8b\u6545\u306e\u8a71\u304c\u3042\u308a\u307e\u3057\u305f\uff08\u53bb\u5e74\u306e7\u6708\u306e\u8a18\u4e8b\u3002\u95b2\u89a7\u6ce8\u610f\uff09\u3002<br \/>\nhttps:\/\/www.science.org\/content\/article\/france-issues-moratorium-prion-research-after-fatal-brain-disease-strikes-two-lab<br \/>\n\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3001ALS\u3082\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u306e\u7570\u5e38\u304c\u539f\u56e0\u3068\u3044\u3046\u8aac\u304c\u6709\u529b\u3067\u3059\u304c\u3001\u6298\u308a\u7573\u307f\u306e\u7570\u5e38\u304c\u300c\u5897\u6b96\u300d\u3059\u308b\u3068\u3044\u3046\u306e\u306f\u4e0d\u601d\u8b70\u3067\u3059\u3002wikipedia \u306b\u6570\u5b66\u7684\u89e3\u6790\u3084\u88dc\u52a9\u7684\u306a\u56e0\u5b50\u304c\u3042\u308b\u3068\u3044\u3046\u8a71\u304c\u51fa\u3066\u3044\u307e\u3059\u3002\u9593\u9055\u3063\u305f\u6298\u308a\u7573\u307f\u306e\u6307\u6570\u95a2\u6570\u7684\u306a\u5897\u6b96\u3092\u9045\u304f\u3067\u304d\u308c\u3070\u6cbb\u7642\u6cd5\u306b\u3064\u306a\u304c\u308b\u3001\u3068\u3044\u3046\u306e\u306f\u5e0c\u671b\u304c\u6301\u3066\u307e\u3059\u306d\u3002<br \/>\nhttps:\/\/en.wikipedia.org\/wiki\/Prion#Prion_replication<br \/>\n\u30d7\u30ea\u30aa\u30f3\u306f\u54fa\u4e73\u985e\u306e\u611f\u67d3\u6027\u306e\u3082\u306e\uff08\uff1d\u975e\u5e38\u306b\u5371\u967a\uff09\u4ee5\u5916\u306b\u3082\u3042\u308b\u3088\u3046\u3067\u3001\u9175\u6bcd\u30d7\u30ea\u30aa\u30f3\u3068\u3044\u3046\u306e\u304c\u826f\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eba\u9593\u306b\u306f\u611f\u67d3\u3057\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u3002<br \/>\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/24390581\/<\/p>\n<p>chaperone \u30b7\u30e3\u30da\u30ed\u30f3<br \/>\nmoratorium  \u30e2\u30e9\u30c8\u30ea\u30a2\u30e0\u3001\u4e00\u6642\u505c\u6b62<br \/>\npathogen \u75c5\u539f\u4f53<br \/>\nrespect safety procedures \u5b89\u5168\u624b\u9806\u3092\u9075\u5b88\u3059\u308b<br \/>\nbovine\u3000\u30a6\u30b7<br \/>\nhiatus\u3000\u3059\u304d\u307e\u3001\u3072\u3073\u3001\u8131\u5b57\u3000\u30cf\u30a4\u300c\u30a8\u300d\u30bf\u30b9 level 11<br \/>\n\u3000We renewed our friendship after a hiatus of twenty years.\u3000\u300020\u5e74\u9593\u97f3\u4fe1\u306a\u304b\u3063\u305f\u304c\u65e7\u4ea4\u3092\u518d\u3073\u6df1\u3081\u305f<br \/>\nexodus \u8131\u51fa\u3001\u79fb\u6c11\u306e\u51fa\u56fd\u3001\u51fa\u30a8\u30b8\u30d7\u30c8 \u300c\u30a8\u300d\u30af\u30bd\u30c0\u30b9 level 10<br \/>\nviewer discretion advised \u95b2\u89a7\u6ce8\u610f<br \/>\ndiscretion \u614e\u91cd\u3001\u601d\u616e\u5206\u5225\u3001\u624b\u52a0\u6e1b\u3001\u81ea\u7531\u88c1\u91cf<br \/>\n Discretion is the better part of valor. \u7528\u5fc3\u306f\u52c7\u6c17\u306e\u5927\u534a \/ \u9003\u3052\u308b\u304c\u52dd<br \/>\n to use discretion \u624b\u52a0\u6e1b\u3059\u308b<br \/>\n I will leave everything to your discretion.  \u4e07\u4e8b\u304d\u307f\u306b\u4efb\u305b\u305f\u3002<br \/>\n to carry out something at one&rsquo;s discretion \u72ec\u65ad\u3067\u884c\u3046\u3002<br \/>\n\u3000<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u304c\u7570\u5e38\u306b\u306a\u3063\u3066\u305d\u308c\u304c\u611f\u67d3\u3059\u308b\u3068\u3044\u3046\u30d7\u30ea\u30aa\u30f3\u75c5\u306f\u4e0d\u601d\u8b70\u306a\u3053\u3068\u304c\u591a\u304f\u3001\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u591a\u6b21\u5143NMR\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5404\u90e8\u5206\u306e\u8ddd\u96e2\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u5f62\u72b6\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u305d\u306e\u5b9f\u9a13\u3068\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6628\u5e74\u767a\u8868\u306e\u7814\u7a76\u306a\u3069\u306f\u9762\u767d\u3044\u3067\u3059\u3002\u307e\u308c\u306a\u904e\u7a0b\u306e\u52b9\u7387\u7684\u306a\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u4f8b\uff08metadynamics\u3001\u3044\u305a\u308c\u89e3\u8aac\u3057\u307e\u3057\u3087\u3046)\u3068\u3057\u3066\u52c9\u5f37\u306b\u306a\u308a\u307e\u3059\u3002 https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2019631118 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