\u4eca\u65e5\u306f\u60b2\u5287\u306e\u30d5\u30e9\u30f3\u30af\u30ea\u30f3\u5317\u6975\u63a2\u691c\u968a(1845)\u3092\u53d6\u308a\u4e0a\u3052\u307e\u3059\u3002
\n\u3053\u308c\u306f\u3001\u5317\u6975\u63a2\u691c\u306e\u6700\u521d\u671f\u306b\u884c\u308f\u308c\u305f\u3001\u30ab\u30ca\u30c0\u306e\u5317\u5074\u3092\u901a\u3063\u3066\u5927\u897f\u6d0b\u3068\u592a\u5e73\u6d0b\u3092\u7d50\u3076\u822a\u8def(\u5317\u897f\u822a\u8def\uff09\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306e\u9060\u5f81\u3067\u3059\u3002\u30a4\u30ae\u30ea\u30b9\u6d77\u8ecd\u809d\u3044\u308a\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u304c\u3001129\u4eba(133\u4eba\uff1f\uff09\u306e\u968a\u54e1\u304c\u5168\u6ec5\u3057\u307e\u3057\u305f\u3002\u5317\u897f\u822a\u8def\u3092\u78ba\u7acb\u3057\u305f\u306e\u306f\u3001\u5357\u6975\u70b9\u4e00\u756a\u4e57\u308a\u306e\u30a2\u30e0\u30f3\u30bb\u30f3(1906)\u3067\u3059\u3002\u512a\u79c0\u306a\u4eba\u306f\u8907\u6570\u306e\u696d\u7e3e\u3092\u4e0a\u3052\u307e\u3059\u306d\u3002\u79c1\u306e\u307f\u308b\u3068\u3053\u308d\u3001\u8981\u56e0\u306f\u624d\u80fd\u3060\u3051\u3067\u306a\u304f\u3001\u6027\u683c\u3084\u4ed5\u4e8b\u306e\u3084\u308a\u65b9\u304c\u5bfe\u8c61\uff08\u3068\u6642\u4ee3\uff09\u306b\u5408\u3063\u3066\u3044\u308b\u5834\u5408\u304c\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u300c\u904b\u300d\u3092\u69cb\u6210\u3059\u308b\u4e00\u3064\u306e\u8981\u7d20\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u5408\u3046\u5bfe\u8c61\u3092\u63a2\u3059\u304b\u3001\u81ea\u5206\u3092\u5909\u3048\u308b\u304b\u3001\u6c17\u306b\u305b\u305a\u81ea\u5206\u3092\u8cab\u304f\u304b\u3001\u4eba\u305d\u308c\u305e\u308c\u3067\u3059\u306d\u3002
\nhttps:\/\/ja.wikipedia.org\/wiki\/%E3%83%95%E3%83%A9%E3%83%B3%E3%82%AF%E3%83%AA%E3%83%B3%E9%81%A0%E5%BE%81<\/p>\n
1\u5e74\u534a\u3001\u6c37\u306b\u9589\u3058\u8fbc\u3081\u3089\u308c\u3066\u304b\u3089\u8239\u3092\u6368\u3066\u305f\u3088\u3046\u3067\u3059\u3002\u898b\u3064\u304b\u3063\u305f\u907a\u4f53\u306e\u5206\u6790\u304b\u3089\u3001\u4f55\u4eba\u304b\u306e\u6b7b\u56e0\u3068\u3057\u3066\u6319\u3052\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u306f\u925b\u4e2d\u6bd2\u3067\u3001\u6d77\u6c34\u3092\u84b8\u7559\u3057\u3066\u98f2\u6599\u6c34\u306b\u3059\u308b\u305f\u3081\u306e\u88c5\u7f6e\u3092\u925b\u3092\u542b\u3080\u306f\u3093\u3060\u4ed8\u3051\u3067\u4f5c\u3063\u3066\u3044\u305f\u305f\u3081\u3001\u307e\u305f\u7f36\u8a70\u306e\u306f\u3093\u3060\u4ed8\u3051\u306e\u925b\u304c\u539f\u56e0\u3068\u3082\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3044\u3046\u7d4c\u9a13\u304c\u3042\u308b\u305f\u3081\u304b\u3001\u6b27\u5dde\u306f\u925b\u306b\u3064\u3044\u3066\u898f\u5236\u3092\u5f37\u3081\u3066\u3044\u307e\u3059(\u925b\u30d5\u30ea\u30fc\u306f\u3093\u3060\u3092\u8981\u6c42\u3059\u308bRoHS\u898f\u5236\u306a\u3069\u3002\u30ea\u30b5\u30a4\u30af\u30eb\u4e0d\u80fd\u306a\u96fb\u5b50\u56de\u8def\u304b\u3089\u74b0\u5883\u306b\u925b\u304c\u51fa\u308b\u306e\u3092\u5acc\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\uff09\u3002\u30da\u30ed\u30d6\u30b9\u30ab\u30a4\u30c8\u592a\u967d\u96fb\u6c60\u306f\u925b\u3092\u542b\u3080\u306e\u3067\u3001\u5b8c\u5168\u30ea\u30b5\u30a4\u30af\u30eb\u304c\u8981\u6c42\u3055\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u4e0b\u8a18\u306b\u3088\u308b\u3068\u925b\u4e2d\u6bd2\u306b\u3088\u308b\u6b7b\u8005\u306f1\u5e74\u9593\u306b\u4e16\u754c\u306754\u4e07\u4eba\u3060\u305d\u3046\u3067\u3059\u3002
\nhttps:\/\/en.wikipedia.org\/wiki\/Lead_poisoning
\n\u822a\u7a7a\u6a5f\u7528\u306b\u306f\u307e\u3060\u6709\u925b\u30ac\u30bd\u30ea\u30f3\uff08\u30c6\u30c8\u30e9\u30a8\u30c1\u30eb\u925b\u3092\u542b\u307f\u3001\u767a\u706b\u6e29\u5ea6\uff08\u767a\u706b\u70b9\uff09\u3092\u4e0a\u6607\u3055\u305b\u308b\u52b9\u679c\u306b\u3088\u3063\u3066\u51fa\u529b\u5411\u4e0a\uff09\u3082\u4f7f\u308f\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002
\n\u6bd2\u6027\u306e\u539f\u56e0\u306f\u3001wikipedia\u306b\u3088\u308b\u3068\u3001\u30e9\u30b8\u30ab\u30eb\u767a\u751f\u306b\u3088\u308bDNA\u640d\u50b7\u3084\u7d30\u80de\u819c\u640d\u50b7\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30a4\u30aa\u30f3\u30c1\u30e3\u30f3\u30cd\u30eb\u306e\u8aa4\u52d5\u4f5c\u3001\u307e\u305f\u786b\u9ec4\u539f\u5b50\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u3044\u308d\u3044\u308d\u306a\u9175\u7d20\u306e\u59a8\u5bb3\u3068\u306e\u3053\u3068\u3002\u4e0b\u8a18\u306f\u9175\u7d20\u304c\u925b\u539f\u5b50\u306b\u7d50\u5408\u3057\u305f\u90e8\u5206\u304c3D\u3067\u898b\u3048\u307e\u3059\u3002
\nhttps:\/\/www.rcsb.org\/3d-view\/1QNV?preset=ligandInteraction&sele=PB<\/p>\n
\u6700\u8fd1\u3001\u30d5\u30e9\u30f3\u30af\u30ea\u30f3\u63a2\u691c\u968a\u306e\u8239\u304c\u6d77\u5e95\u3067\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u9060\u304b\u3089\u305a\u3044\u308d\u3044\u308d\u306a\u8b0e\u304c\u308f\u304b\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002
\nhttps:\/\/style.nikkei.com\/article\/DGXMZO50761400Y9A001C1000000\/<\/p>\n
The harmful effects of lead are myriad. \u925b\u306e\u6709\u5bb3\u306a\u5f71\u97ff\u306f\u7121\u6570\u306b\u3042\u308b\u3002
\nmyriad \u300c\u30df\u300d\u30ea\u30a2\u30c3\u30c9\u3000\u7121\u6570
\ntranscription \u8ee2\u5199
\nsolder \u306f\u3093\u3060
\nsoldering \u306f\u3093\u3060\u4ed8\u3051
\n\u767a\u706b\u70b9\u3000firing point; burning point; ignition point; fire point
\nanemia\u3000\u30a2\u300c\u30cb\u300d\u30df\u30a2\u3000\u8ca7\u8840 brain anemia \u8133\u8ca7\u8840
\nhypotention \u30cf\u30a4\u30dd\u30c6\u30f3\u30b7\u30e7\u30f3\u3000\u4f4e\u8840\u5727\u75c7
\nhypertetion \u30cf\u30a4\u30d1\u30fc\u30c6\u30f3\u30b7\u30e7\u30f3\u3000\u9ad8\u8840\u5727\u75c7
\nacute porphyria \u6025\u6027\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u75c7\u3000\uff08\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u5408\u6210\u9175\u7d20\u306e\u4e0d\u8abf\u3067\u4f53\u5185\u306e\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u304c\u5897\u3048\u3001\u6392\u305b\u3064\u7269\u304c\u7d2b\u8272\u306b\u306a\u308b\uff09\u3000porphyrin \u306f\u30e9\u30c6\u30f3\u8a9e\u3067\u7d2b\u8272\u306e\u8272\u7d20\u306e\u610f\u5473\u3060\u305d\u3046\u3067\u3059\u3002
\nLead is able to pass through the endothelial cells at the blood brain barrier because it can substitute for calcium ions and be uptaken by calcium-ATPase pumps. \u925b\u306f\u8133\u8840\u6d41\u95a2\u9580\u306e\u5185\u76ae\u7d30\u80de\u3092\u901a\u904e\u3059\u308b\u3002\u305d\u308c\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u7f6e\u63db\u3057\u3066\u30ab\u30eb\u30b7\u30a6\u30e0-ATPase\u30dd\u30f3\u30d7\u304b\u3089\u5438\u3044\u4e0a\u3052\u3089\u308c\u308b\u305f\u3081\u3067\u3042\u308b\u3002
\ncerebral cortex \u5927\u8133\u76ae\u8cea\u3000\u30bb\u300c\u30ec\u300d\u30d6\u30e9\u308b \u3068\u300c\u30bb\u300d\u30ec\u30d6\u30e9\u308b\u3000\u306e\u4e21\u65b9\u306e\u30a2\u30af\u30bb\u30f3\u30c8\u304c\u3042\u308a\u307e\u3059\u3002\u3000\u300c\u30b3\u30fc\u300d\u30c6\u30c3\u30af\u30b9
\nPb2+, like Mg2+, block NMDA receptors. Therefore, an increase in Pb2+ concentration will effectively inhibit ongoing long-term potentiation (LTP), and lead to an abnormal increase in long-term depression (LTD) on neurons in the affected parts of the nervous system. \u3000\u3053\u308c\u306f\u8aad\u3081\u307e\u3059\u306d\u3002
\n\u203b\u3000NMDA(N-\u30e1\u30c1\u30eb-D-\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178)\u5236\u5fa1\u578b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53\uff08Na+,K+,Ca2+\u7528\u30a4\u30aa\u30f3\u30c1\u30e3\u30f3\u30cd\u30eb\uff09\u306eMg2+\u306b\u3088\u308b\u30d6\u30ed\u30c3\u30af\u306f\u6b63\u5e38\u52d5\u4f5c\u306a\u306e\u3067\u3059\u304c\uff08\u5fdc\u7b54\u306b\u975e\u7dda\u5f62\u6027\u30fb\u6642\u9593\u4f9d\u5b58\u6027\u3092\u4e0e\u3048\u308b\uff09\u3001Pb2+\u306f\u540c\u69d8\u306b\u30d6\u30ed\u30c3\u30af\u3059\u308b\u304c\u6319\u52d5\u304c\u9055\u3046\u306e\u3067\u795e\u7d4c\u6bd2\u6027\uff08\u9707\u3048\u3001\u6027\u683c\u7570\u5e38\u3001\u75f4\u5446\uff09\u304c\u51fa\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u795e\u7d4c\u306f\u5316\u5b66\u3068\u96fb\u6c17\u306e\u4e21\u65b9\u304c\u51fa\u3066\u304d\u3066\u9762\u767d\u3044\u306e\u3067\u3001\u6539\u3081\u3066\u89e3\u8aac\u306e\u6a5f\u4f1a\u3092\u8a2d\u3051\u305f\u3044\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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